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Any word on Prof Roy Taylor's Retune Study ?

zand said:
Cherry picking participants again then.
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I would love to see the MRI of someone with a BMI of <20 with T2.
Just to see if his visceral fat theory holds water across all ranges.

I've seen Michael Mosleys scan here
https://thebloodsugardiet.com/michaels-story/

He was 86kg at diagnosis & I'd guess his height to be 5'10", that puts his BMI at 27.
All guesswork of course.
A 9kg weight loss worked for him giving him a new BMI of 24.
 
According to the DuK briefing on research they were going ahead with it but as with all things DuK they are very vague and extremely centralised.
But given Direct is very much their baby and they are keen to promote remission via the Newcastle Diet above all other methods, I can't imagine they would not be funding this still and it is listed on their list of research projects.
 
Ronancastled said:
Official preview release here

https://www.diabetes.org.uk/about_us/news/retune-remission-study-preview
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I wonder how they will be able to motivate quite slim people albeit with a tummy, to lose weight on 800 kcals where the only perceived benefit may be remission ? I understand that the shakes are the quickest way to prove the hypothesis and that they keep the food macros consistent.
I'd love to see an RCt in which patients were given sufficient calories to maintain their weight but where the carb ratios were tweaked. Then the scans could show differences in visceral fat alongside metabolic results.
 
They wouldn’t take me on. They said my BMI at 21 was too low. I thought they were looking for slim type 2s. Oh well.
 
NicoleC1971 said:
I wonder how they will be able to motivate quite slim people albeit with a tummy, to lose weight on 800 kcals where the only perceived benefit may be remission
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My motivation was/is to prevent complications. I'm already partially sighted due to other reasons and would happily starve myself to retain the bit I have left.
Reading the report it's only 800 cals for 2 weeks at a time.
And, yes I would prefer to do it lc.

Does any one know, is it actually proven that tummy fat causes diabetes, or is it just a result of something else (insulin resistance?) going on?
I'm just wondering if this is another example of concentrating on symptoms rather than root causes
 
Actually, the Re-TUNE researchers hypothesize that it visceral fat that causes diabetes rather than being obese per se:-

"The cause of type 2 diabetes in non-obese people was thought to be different from in obese people, but results of experiments do not support this view. An alternative idea is that people have a personal level of total body fat that they can tolerate and if they go above that level, they develop diabetes. Re-TUNE will study whether weight loss in people with type 2 diabetes who are not obese can reverse their condition, which would support the idea of a personal fat threshold." https://www.dtu.ox.ac.uk/OurTrials/ReTune.php​
 
Bit more detail here:
https://www.eurekalert.org/news-releases/929487

 
Speedbird said:
They wouldn’t take me on. They said my BMI at 21 was too low. I thought they were looking for slim type 2s. Oh well.
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As they are aiming for a 10-15% weight-loss, it's likely that with your BMI you would end up as being underweight which wouldn't be ethical:-

"People on the ReTUNE trial are being asked to consume 800 calories a day (from soups, shakes and non-starchy vegetables) for up to two weeks while being supervised by a medical team. After this, they are supported to gradually return to eating normal food and to keep off the weight they lost.

This cycle of a low-calorie diet and weight loss maintenance is repeated up to three times, until they have lost 10-15% of their body weight. After each cycle, the research team is measuring the amount of fat in the pancreas and liver and looking to see who has gone into remission." https://www.diabetes.org.uk/about_u...r&utm_campaign=retune_preview&utm_term=280921​
 
Seems like a disastrous diet. Protect lean mass at all costs. Alternating weeks of maintenance/protein sparing modified fasting would be much safer/manageable.

anyone know the macros of the shakes?
 
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