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Message: <blockquote data-quote="mfactor" data-source="post: 1133534" data-attributes="member: 67718">From what I understand Metformin works by building up in your system and has no effect directly on post meal levels, you only take it with a meal to mitigate stomach upset...I take both mine with my lunch, I used to have stomach problems with them but pretty good now, I can even take them with no food in a pinch....So would say if you have stomach probs take them as far apart as you can (with food),... so you can deal with them one at a time...But when I had problems with them to begin with I liked to get then all down before 6pm , simply because if my stomach played up I wanted to be able to rush to the loo, could be nasty if you were asleep <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite9" alt=":eek:" title="Eek!    :eek:" loading="lazy" data-shortname=":eek:" /> if you get my drift <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile    :)" loading="lazy" data-shortname=":)" /></blockquote>

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