apothecary
Member
- Messages
- 7
- Location
- East Anglia
- Dislikes
- western diet and the "food" industry. ignorance (others AND mine!)
Hi World. This my first post. I have typeI for 40 years. My brother has had for 20 years. My Mum had insulin on diagnosis in her 40s.
I am a health professional and shocked with the realisation that - I suffer from Aspergers syndrome and currently a very severe depression which a kind colleague pulled me to one side one day and said go and get help. I am trying. I have a lot of aches pains cramps - taken statins for 5 years and had to stop as my waist was balloning and then became isulin resistant with lantus levels climbing to 100% previously ( I have heard this happen to others - will come back to this later) I stopped statins and muscle problems improved a bit.
My muscles ache and are weak I did have bilateral frozen shoulders about 4 years ago and what I found called a cheiro-arthropathy even though my diabetes specialist seemed not interested in this and I had to give up on my rheumatologist who seemed un-interested because my inflammatory markers were not raised.......
I used the skills I have been born with to read and analyze data from several research centres since about 1988 and the results have just shocked me. I have searched c-peptide on this forum and found very few mentions - except it's use in the diagnosis of the type of diabetes you have BUT:
1)Islet cells store BOTH insulin AND c-peptide and guess what - they release insulin AND c-petide - this implies BOTH are essential - our modern insulins, since monocomponent times, have had all of the other peptide fragments removed (or they were never there in the first place......)
2)patients with type 1 who continue to produce basal levels of c-petide (yes this can happen) seem to be protected from the complications of diabetes ( interesting because binding site of c-peptide to the K+ATPase is saturated at LOW levels in normal and diabetic subjects (the amounts of insulin these people produce are also small but because of the different receptor site binding of insulin I suspect this effect is negligable - implying a "honey moon" period for C-peptide which would be longer for type1s).
3)I have also found trials concerning TREATING "diabetic complications" with c-peptide which is being fast tracked through the FDA ..... results concer nerve conduction studies but also other "complications"
4) trials about control of diabetes have had dissappointing results in terms of clearly correlating good control with reduced complications - there is no doubt that a normal glucose level is essential to aim for BUT I have personally known well controlled and reasonably controlled type 1s who seem to struggle with complications ( I am attending the funeral of another family member next week who died form renal failure in early 50s. the youngest diabetic with type 1 who died from complications that I know about was 22 and the sibling developed type 1 and had to undergo dialysis aged 18.
5) c-peptide seems to have a crucial role in a membrane protein with a specific receptor site in many tissues mainly connective tissues including fibroblasts and smooth muscle - the active site in c-peptide (-COOH end and made up of glycine rich region of 6AA)is conserved throughout many mammal species studied although like with insulin the structural components do differ between species
I understand a consultant nephrologist in leicester( on youtube) is looking to raise funds for research - my shock is how little the medical profession I have encountered seems to understand the significance of this. Does this help to explain wy this forum is littered with people whose symptoms get worse on the synthetic insulins and yearn a return to the older insulins???? Maybe islet cell transplants return normal c-peptide functioning so those folks are treating the wrong condition with the right treatment.??
I have an interest in a whole load of peptide fragments released by the gut which serve endocrine and paracrine functions and c-peptide seems to be one of the more important of these. This all fits a pattern and seems like a "Banting and Best moment" in my understanding of type 1 diabetes may not just be a deficiency of insulin BUT also of c-peptide deficiency......
BTW - starting metformin gave me expected change in bowel habit ( now normal again.....) does metformin alter peptide production in the bowel - this would fit with it being the major contributor in improving mortality in all the large trials DESPITE not having a major effect on HbA1c!!!
- I have stopped statins - it felt like I was developing type2 diabetes on top of type 1 my lantus level is now down to 50% which must be good as high levels of insulin cannot be good.
I have posted this to try and get some discussion. I am sorry it is a long post - I have tried to stick with reporting factually on various trials but am aware I have not given references. I apologise if this discussion is being held elsewhere in the forum but it would be of particular interest to type1s mainly. thank you for your patience, I have been really ill recently - it makes me laugh when they ask patients with diabetes are you low or unhappy - " yeah I am fed up sticking needles in me every day!!"
apothecary
I am a health professional and shocked with the realisation that - I suffer from Aspergers syndrome and currently a very severe depression which a kind colleague pulled me to one side one day and said go and get help. I am trying. I have a lot of aches pains cramps - taken statins for 5 years and had to stop as my waist was balloning and then became isulin resistant with lantus levels climbing to 100% previously ( I have heard this happen to others - will come back to this later) I stopped statins and muscle problems improved a bit.
My muscles ache and are weak I did have bilateral frozen shoulders about 4 years ago and what I found called a cheiro-arthropathy even though my diabetes specialist seemed not interested in this and I had to give up on my rheumatologist who seemed un-interested because my inflammatory markers were not raised.......
I used the skills I have been born with to read and analyze data from several research centres since about 1988 and the results have just shocked me. I have searched c-peptide on this forum and found very few mentions - except it's use in the diagnosis of the type of diabetes you have BUT:
1)Islet cells store BOTH insulin AND c-peptide and guess what - they release insulin AND c-petide - this implies BOTH are essential - our modern insulins, since monocomponent times, have had all of the other peptide fragments removed (or they were never there in the first place......)
2)patients with type 1 who continue to produce basal levels of c-petide (yes this can happen) seem to be protected from the complications of diabetes ( interesting because binding site of c-peptide to the K+ATPase is saturated at LOW levels in normal and diabetic subjects (the amounts of insulin these people produce are also small but because of the different receptor site binding of insulin I suspect this effect is negligable - implying a "honey moon" period for C-peptide which would be longer for type1s).
3)I have also found trials concerning TREATING "diabetic complications" with c-peptide which is being fast tracked through the FDA ..... results concer nerve conduction studies but also other "complications"
4) trials about control of diabetes have had dissappointing results in terms of clearly correlating good control with reduced complications - there is no doubt that a normal glucose level is essential to aim for BUT I have personally known well controlled and reasonably controlled type 1s who seem to struggle with complications ( I am attending the funeral of another family member next week who died form renal failure in early 50s. the youngest diabetic with type 1 who died from complications that I know about was 22 and the sibling developed type 1 and had to undergo dialysis aged 18.
5) c-peptide seems to have a crucial role in a membrane protein with a specific receptor site in many tissues mainly connective tissues including fibroblasts and smooth muscle - the active site in c-peptide (-COOH end and made up of glycine rich region of 6AA)is conserved throughout many mammal species studied although like with insulin the structural components do differ between species
I understand a consultant nephrologist in leicester( on youtube) is looking to raise funds for research - my shock is how little the medical profession I have encountered seems to understand the significance of this. Does this help to explain wy this forum is littered with people whose symptoms get worse on the synthetic insulins and yearn a return to the older insulins???? Maybe islet cell transplants return normal c-peptide functioning so those folks are treating the wrong condition with the right treatment.??
I have an interest in a whole load of peptide fragments released by the gut which serve endocrine and paracrine functions and c-peptide seems to be one of the more important of these. This all fits a pattern and seems like a "Banting and Best moment" in my understanding of type 1 diabetes may not just be a deficiency of insulin BUT also of c-peptide deficiency......
BTW - starting metformin gave me expected change in bowel habit ( now normal again.....) does metformin alter peptide production in the bowel - this would fit with it being the major contributor in improving mortality in all the large trials DESPITE not having a major effect on HbA1c!!!
- I have stopped statins - it felt like I was developing type2 diabetes on top of type 1 my lantus level is now down to 50% which must be good as high levels of insulin cannot be good.
I have posted this to try and get some discussion. I am sorry it is a long post - I have tried to stick with reporting factually on various trials but am aware I have not given references. I apologise if this discussion is being held elsewhere in the forum but it would be of particular interest to type1s mainly. thank you for your patience, I have been really ill recently - it makes me laugh when they ask patients with diabetes are you low or unhappy - " yeah I am fed up sticking needles in me every day!!"
apothecary
