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Can insulin be formed again in type 1 diabetes
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<blockquote data-quote="GrantGam" data-source="post: 1465446" data-attributes="member: 295621"><p>Many thanks for the lengthy and belittling reply [USER=393050]@Hoping4Cure[/USER]; it's much appreciated...</p><p></p><p>Just so you know, I was taking the OP's query regarding the 'production of insulin again' as a permanent and substantial change; not a negligible and fluctuating variance. I'd imagine that there can be considerable accuracy issues with C-peptide testing as well.</p><p></p><p>You appear to have largely misinterpreted my post however; as I still believe that the pancreas cannot regain functionality (and we're talking non-negligable amounts here) when a T1D. You mentioned "halting auto-immunity" and if that were to occur, the beta cells would stop being wiped out. I fully agree. But as T1's, that auto-immune response can't be halted (because we don't know how) and that's where the problem lies; cells are made and then killed off. So because of that, there's not going to be any pancreatic functionality (regarding insulin production) that's really worth mentioning. </p><p></p><p>I never once said that reversing type 1 diabetes is virtually impossible; you're misquoting me entirely there. I'm sure T1 can be reversed - but as of yet, no-one knows how. The auto-immune response needs to be addressed and it's yet to be entirely understood.</p><p></p><p>What is virtually impossible though, is someone with T1D to suddenly produce sufficient amounts of insulin again. I've only heard of one British man to date (fairly recently actually), but as far as I know - there have been no conclusive answers as to why this happened.</p><p></p><p>Please don't attempt to belittle me again in the future [USER=393050]@Hoping4Cure[/USER].</p></blockquote><p></p>
[QUOTE="GrantGam, post: 1465446, member: 295621"] Many thanks for the lengthy and belittling reply [USER=393050]@Hoping4Cure[/USER]; it's much appreciated... Just so you know, I was taking the OP's query regarding the 'production of insulin again' as a permanent and substantial change; not a negligible and fluctuating variance. I'd imagine that there can be considerable accuracy issues with C-peptide testing as well. You appear to have largely misinterpreted my post however; as I still believe that the pancreas cannot regain functionality (and we're talking non-negligable amounts here) when a T1D. You mentioned "halting auto-immunity" and if that were to occur, the beta cells would stop being wiped out. I fully agree. But as T1's, that auto-immune response can't be halted (because we don't know how) and that's where the problem lies; cells are made and then killed off. So because of that, there's not going to be any pancreatic functionality (regarding insulin production) that's really worth mentioning. I never once said that reversing type 1 diabetes is virtually impossible; you're misquoting me entirely there. I'm sure T1 can be reversed - but as of yet, no-one knows how. The auto-immune response needs to be addressed and it's yet to be entirely understood. What is virtually impossible though, is someone with T1D to suddenly produce sufficient amounts of insulin again. I've only heard of one British man to date (fairly recently actually), but as far as I know - there have been no conclusive answers as to why this happened. Please don't attempt to belittle me again in the future [USER=393050]@Hoping4Cure[/USER]. [/QUOTE]
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