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We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars.
phraedus said:I would have expected that the now-documented use of false claims would have enabled the FDA to have taken legal action against the purveyors of Benfotiamine.
CactusCritter - Jun 13, 2008
* Rank: 5 / 5 (1)
I would have expected that the now-documented use of false claims would have enabled the FDA to have take legal action against the purveyors of Benfotiamine.
Benfotiamine is converted to thiamine, but given the facts that:
• benfotiamine is not endogenous in humans,
• the bioavailability of thiamine from benfotiamine is higher than that of other
sources of thiamine,
• benfotiamine in its dephosphorylated form is absorbed and bioavailable,
• no toxicological studies have been provided for benfotiamine to evaluate
reproductive and developmental toxicity, genotoxicity or long term toxicity of
benfotiamine, and
• the animal and clinical studies referred to, which were without adverse effects,
were not designed to study possible adverse effects of benfotiamine,
the Panel concludes that the submitted data are insufficient to demonstrate the safety of the
proposed use and use levels of benfotiamine.
Dr. Victoria King, Head of Research at Diabetes UK said “Diabetes UK is pleased to have supported this research and is encouraged by these promising results which now need to be tested and confirmed in human trials. We would like to note that it’s still too early to draw any firm conclusions about the role of vitamin B1 in the prevention of complications and we would not advise that people look to vitamin supplements to reduce their risk of cardiovascular complications at this stage. Taking your prescribed medication, eating a healthy balanced diet and taking regular physical activity are key to good diabetes management and therefore reducing your risk of diabetes associated complications.”
except that those purveyers carefully word their claims and include a disclaimer such as thisphraedus said:I would have expected that the now-documented use of false claims would have enabled the FDA to have taken legal action against the purveyors of Benfotiamine.
Because benfotiamine is a dietary supplement the FDA only requires manufacturers and distributors to have credible evidence as to its safety. The FDA itself has not evaluated benfotiamine for safety or effectiveness. Benfotiamine therefore cannot be represented to diagnose, treat, cure or prevent any disease.
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