• Guest, the forum is undergoing some upgrades and so the usual themes will be unavailable for a few days. In the meantime, you can use the forum like normal. We'd love to know what you think about the forum! Take the 2025 Survey »

Can Neuropathy be reversed?

Can I refer you to my earlier answers regarding this supposed deficiency/non deficiency.........

Have a read of this LA Times article........it says it all.......

http://www.latimes.com/health/la-he-fit ... 3222.story

You seem to be repeating what has already been posted here by my old pal soundgen. Are you a friend of his by any chance..........not Gerry are you ? :wink:

I'll leave you to it I think....... I can't be bothered to repeat what has gone before. Head and brick wall come to mind.
 

Attachments

  • banghead.gif
    banghead.gif
    904 bytes · Views: 1,718
I started benfotiamine to see if it would resolve the burning tingling sensation in my hands and it did. I take 300mg/d.

If you experience a hyperglycemic event and do not shunt the glycolitic metabolites to the pentose phosphate pathway they will be used in the formation of AGE ; the hexosamine pathway and DAG protien kinase pathway that are all implicated in diabetic complications.

Perhaps I am not taking enough benfotiamine to access the pentose phosphate pathway but I hope I am as for the neuropathy question yes it did resolve mine.

As for the fourth pathway the polyol pathway google polyol pathway vitamin c sorbitol another vitamin in our quiver against diabetic complications.

We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars.

http://www.nature.com/nm/journal/v9/n3/abs/nm834.html
 
I would have expected that the now-documented use of false claims would have enabled the FDA to have taken legal action against the purveyors of Benfotiamine.
 
phraedus said:
I would have expected that the now-documented use of false claims would have enabled the FDA to have taken legal action against the purveyors of Benfotiamine.

phraedus.........

Now isn't that a coincidence ? You have posted something that almost EXACTLY matches this........

CactusCritter - Jun 13, 2008

* Rank: 5 / 5 (1)

I would have expected that the now-documented use of false claims would have enabled the FDA to have take legal action against the purveyors of Benfotiamine.

That was posted as a response to the article I quoted earlier. As this is a UK site I have no idea why the FDA have maybe not done anything about the documented false claims. Perhaps you should ask them yourself.

The European Food Standards Agency have commented about Benfotiamine back in 2008......

Benfotiamine is converted to thiamine, but given the facts that:
• benfotiamine is not endogenous in humans,
• the bioavailability of thiamine from benfotiamine is higher than that of other
sources of thiamine,
• benfotiamine in its dephosphorylated form is absorbed and bioavailable,
• no toxicological studies have been provided for benfotiamine to evaluate
reproductive and developmental toxicity, genotoxicity or long term toxicity of
benfotiamine, and
• the animal and clinical studies referred to, which were without adverse effects,
were not designed to study possible adverse effects of benfotiamine,
the Panel concludes that the submitted data are insufficient to demonstrate the safety of the
proposed use and use levels of benfotiamine
.

http://www.efsa.europa.eu/en/scdocs/doc/864.pdf

In my experience there are many odd and false claims that seem to be allowed to run, even here in the UK........usually it's because whilst the claims may be false and based on unsound science, more work and evidence is needed not only to prove the claims, but also to disprove them too. In other words they have better things to do than spend large sums of money on disproving unsubstantiated claims by some 'purveyors' of stuff such as this. Mostly they rely on people using their common sense and seeing the claims for what they are.........promotion of something that makes somebody a lot of money.

Now if you and others want to waste money on a supplement that at best MAY have some benefit rather than a proven benefit........well, that is your choice. Just don't 'parrot' the psuedo-science on here as if it is a proven fact and is incontrovertible. Some of us are not so gullible and can see when something is being touted as a cure all.......with little or no proof that it actually has any benefit at all. There is only anecdotal evidence that it MAY be. I deal in hard facts and so far I have seen none that Benfotiamine does much. A few people on here who swear by it........who always push it as the thing to take because it has soooooo many benefits. They seem to have some sort of agenda to keep it in the spotlight........are they connected in some way to the 'purveyors' of this stuff ? Who knows, but something tells me that Fish I had the other day is going off.........must get rid of it methinks :wink:

This is the latest research carried out at the University of Bristol by Professor of Experimental Cardiovascular Medicine, Paolo Madeddu who said, "Supplementation with benfotiamine from early stages of diabetes improved the survival and healing of the hearts of diabetic mice that have had heart attacks, and helped prevent cardiovascular disease in mice with both Type 1 and Type 2 diabetes. We conclude that benfotiamine could be a novel treatment for people with diabetes, and the next step in this research will be testing whether similar effects are seen in humans."

The DUK response 6/12/2010......
Dr. Victoria King, Head of Research at Diabetes UK said “Diabetes UK is pleased to have supported this research and is encouraged by these promising results which now need to be tested and confirmed in human trials. We would like to note that it’s still too early to draw any firm conclusions about the role of vitamin B1 in the prevention of complications and we would not advise that people look to vitamin supplements to reduce their risk of cardiovascular complications at this stage. Taking your prescribed medication, eating a healthy balanced diet and taking regular physical activity are key to good diabetes management and therefore reducing your risk of diabetes associated complications.”

Seems the research is ongoing........nothing proven, unless you are a mouse.......eek eek ! I go along with Dr Victoria King (no connection).........I think her conclusions say it better than I.
 
If peripheral neuropathy in your hands/legs is a problem from a symptom point of view then medications such as pregabalin or gabapentin sometimes work really well
 
phraedus said:
I would have expected that the now-documented use of false claims would have enabled the FDA to have taken legal action against the purveyors of Benfotiamine.
except that those purveyers carefully word their claims and include a disclaimer such as this
Because benfotiamine is a dietary supplement the FDA only requires manufacturers and distributors to have credible evidence as to its safety. The FDA itself has not evaluated benfotiamine for safety or effectiveness. Benfotiamine therefore cannot be represented to diagnose, treat, cure or prevent any disease.

As Cugila says, be wary how you treat these claims. The supplement industry is just as much multi-billion industry as big 'pharma' just not so well regulated.
 
Back
Top