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<blockquote data-quote="Winnie53" data-source="post: 2266045" data-attributes="member: 160246"><p>From The Lancet, May 20, 2020</p><p></p><p><strong>Vitamin-D and COVID-19: do deficient risk a poorer outcome?</strong></p><p><a href="https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30183-2/fulltext" target="_blank">https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30183-2/fulltext</a></p><p></p><p>The article is a brief, easy read but here are a few excerpts...</p><p></p><p style="margin-left: 20px"><em>"...a <a href="http://dx.doi.org/10.1136/bmj.i6583" target="_blank">2017 meta-analysis</a> of individual patient data from 11 321 participants in 25 randomised controlled trials showed that vitamin D supplementation protected against acute respiratory tract infections and that patients with very low (<25 nmol/L) serum 25-hydroxyvitamin D concentrations (a marker of vitamin D status) gained the most benefit."</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">-----</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>"A role for vitamin D in the response to COVID-19 infection could be twofold. First, vitamin D supports production of antimicrobial peptides in the respiratory epithelium, thus making infection with the virus and development of COVID-19 symptoms less likely. Second, vitamin D might help to reduce the inflammatory response to infection with SARS-CoV-2. Deregulation of this response, especially of the renin–angiotensin system, is characteristic of COVID-19 and degree of overactivation is associated with poorer prognosis. Vitamin D is known to interact with a protein in this pathway—angiotensin-converting enzyme 2 (ACE2)—which is also exploited by SARS-CoV-2 as an entry receptor. While SARS-CoV-2 downregulates expression of ACE2, vitamin D promotes expression of this gene."</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">-----</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>"Adrian Martineau (Institute of Population Health Sciences, Barts and The London, Queen Mary University of London, UK), lead author of the 2017 meta-analysis has joined with colleagues from universities around the UK to launch <a href="https://www.qmul.ac.uk/covidence/" target="_blank">COVIDENCE UK</a>, a study to investigate how diet and lifestyle factors might influence transmission of SARS-CoV-2, severity of COVID-19 symptoms, speed of recovery, and any long-term effects. They aim to recruit at least 12 000 people and to obtain interim results by the summer. Despite his enthusiasm for the study, Martineau is pragmatic: “At best vitamin D deficiency will only be one of many factors involved in determining outcome of COVID-19, but it's a problem that could be corrected safely and cheaply; there is no downside to speak of, and good reason to think there might be a benefit”."</em></p> <p style="margin-left: 20px"></p><p>After doing quite a bit of reading on this, my husband and I settled on taking 4,000 IU (100 mcg) of vitamin D3 a day.</p></blockquote><p></p>
[QUOTE="Winnie53, post: 2266045, member: 160246"] From The Lancet, May 20, 2020 [B]Vitamin-D and COVID-19: do deficient risk a poorer outcome?[/B] [URL]https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30183-2/fulltext[/URL] The article is a brief, easy read but here are a few excerpts... [INDENT][I]"...a [URL='http://dx.doi.org/10.1136/bmj.i6583']2017 meta-analysis[/URL] of individual patient data from 11 321 participants in 25 randomised controlled trials showed that vitamin D supplementation protected against acute respiratory tract infections and that patients with very low (<25 nmol/L) serum 25-hydroxyvitamin D concentrations (a marker of vitamin D status) gained the most benefit."[/I] ----- [I]"A role for vitamin D in the response to COVID-19 infection could be twofold. First, vitamin D supports production of antimicrobial peptides in the respiratory epithelium, thus making infection with the virus and development of COVID-19 symptoms less likely. Second, vitamin D might help to reduce the inflammatory response to infection with SARS-CoV-2. Deregulation of this response, especially of the renin–angiotensin system, is characteristic of COVID-19 and degree of overactivation is associated with poorer prognosis. Vitamin D is known to interact with a protein in this pathway—angiotensin-converting enzyme 2 (ACE2)—which is also exploited by SARS-CoV-2 as an entry receptor. While SARS-CoV-2 downregulates expression of ACE2, vitamin D promotes expression of this gene."[/I] ----- [I]"Adrian Martineau (Institute of Population Health Sciences, Barts and The London, Queen Mary University of London, UK), lead author of the 2017 meta-analysis has joined with colleagues from universities around the UK to launch [URL='https://www.qmul.ac.uk/covidence/']COVIDENCE UK[/URL], a study to investigate how diet and lifestyle factors might influence transmission of SARS-CoV-2, severity of COVID-19 symptoms, speed of recovery, and any long-term effects. They aim to recruit at least 12 000 people and to obtain interim results by the summer. Despite his enthusiasm for the study, Martineau is pragmatic: “At best vitamin D deficiency will only be one of many factors involved in determining outcome of COVID-19, but it's a problem that could be corrected safely and cheaply; there is no downside to speak of, and good reason to think there might be a benefit”."[/I] [/INDENT] After doing quite a bit of reading on this, my husband and I settled on taking 4,000 IU (100 mcg) of vitamin D3 a day. [/QUOTE]
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