dapagliflozin and raised blood glucose

Hi all,

After a few years on Metformin I became fairly intolerant of it and it has been recently swapped for dapagliflozin.

My blood glucose on metformin was usually around 6 ish. It rose to about 12 after a three month break. I have just started on Dapagliflozin this week and after three days on dapagliflozin my blood glucose has shot up to a morning fasting 15 and even higher this afternoon.

As it’s a Friday I am going to give it the weekend to see if it settles down before contacting the practice nurse but has anyone else seen a similar rise in starting dapagliflozin?

As an update to the above…

After starting on dapagliflozin and my blood glucose shooting up to nearly 20 it dropped back down to around 10 to 12 which is around the same as it was three months after dropping metformin and before starting dapagliflozin.

So after two weeks on dapagliflozin it doesn’t seem to be that effective for me. I do notice an increased thirst and more frequent visits to the loo!

I will get the holiday out of the way and have a word with the diabetic nurse but I would be interested in your experiences in starting with dapagliflozin and it’s effectiveness for you.

Sparky

Hi Rachox, Thanks for the welcom.

I would say my diet is usually pretty good and not too carb heavy. I was diagnosed about ten years ago and went through the usual diet changes and a few changes of meds to get me where I am now so I think diet is being managed ok. At least our diabetic nurse didn’t raise any issues at my last review.

Sitaglyptin, metformin and diet brought my fasting glucose down to about six to seven (weight about 11st 5, so ok for a male my size). The metformin was stopped for three months as really struggled with upset stomach and bowel and it was swapped out for dapagliflozin.

After the three month break my glucose was up to about 12 which was about as I expected. Once I started on dapagliflozin it seemed to shoot up to 14 with occasional daytime readings reaching almost 20. Although it’s still early days I haven’t seen a fasting glucose reading lower than about 10.5. It does seem to be having an effect on other things as I am always thirsty now and need more frequent trips to the loo.

Its still early days but rather than wait for my three month HbA1c reading I probably need a conversation with the practice nurse, but I was just wonder what experiences other had when starting out with dapagliflozin in case I am expected too much too soon.

Update 2…..

After developing a raging thirst and many, many visits to the loo I saw the diabetic nurse and after a finger prick test (25 three hours after toast for breakfasts!) she felt I wasn’t responding to dapagliflozin well.

So now I am startling on gliclazide along with my usual sitagliptin. The nurse did suggest that this may not work as she suspects my insulin stores my be depleted and the next step would be referral to check this.

I haven’t seen any bg improvement yet but it’s only been a couple of days Fingers crossed that this and cutting down carbs a bit will help.

Thanks for the replie, they are very helpful.

No problem with ketones, it was 0.2 when she took the bg test of 25. No signs of any acidosis symptoms either.

Fasting bg today was 12. It went up to 19 two hours after two slices of toast. After a lunch of a tin of cream of chicken soup, no extra carbs, it was still 18.

When I was taking metformin my fasting bg was between 5 and 7 so it was effective with my current diet at the time. Sadly I became very intolerant of it, hence the changes. I will be pushing for a referral and although I don’t have a carb heavy diet I will explore cutting back more.