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Prediabetes Do beta cells get destroyed progressively in type2?
- Thread starter saky
- Start Date
Personally I think that T2 is a condition of hyper insulinaemia so unless it has run for quite a few years untreated its unlikely that your beta cells are not producing enough.. more like your body is resistant to what is already over produced.
saky
Well-Known Member
Earlier in 2006 my fasting insulin was 13.22 units, 2013 it was 17 units...
In 2019 I got high hba1c of 5.9%. I lost weight , went low carbon, exercised etc...in 2023 jan fasting insulin is 6.16 units. If I eat high carbs, sugar spikes.
Will insulin production further deteriorate?
Will insulin resistance worsen ?
Your insulin production is normalising?
Nothing to be worried about.. depends on the units of course..
I'm interested in where you are that you can get fasting insulin tested.. Its incredibly hard to get done in the UK if not almost impossible.
Oldvatr
Expert
- Messages
- 8,453
- Type of diabetes
- Type 2
- Treatment type
- Tablets (oral)
The c-peptide test measures how much insulin you are able to produce. So a T2D may be overproducing insulin as BB mentions, so the higher results may reflect the overproduction due to your condition. Your low carbing will have reduced the need to produce high output levels, so again, you have normalised your production to match the need.
There is evidence from old studies that suggest that beta cell output in T2D does decrease which is why previous generations progressed to insulin therapy. We are in recent times seeing this trend being slowed and maybe even reversed by new interventions and medications. So the jury appears to be out on this. The Newcastle Diet study suggests that ectopic fat buildup in the pancreas is responsible for the deterioration, but IMO that is oversimplistic and that there are other factors at play such as Insulin resisance. There is also a theory that beta cells change into alpha cells (de-differentiation) and stop producing insulin. So far there is no evidence to support this theory, and it it were true then the cells would be working in a way that does not occur in any other body cells.
So my answer to the OP is a possible maybe., or even a logical perhaps but my advice is to kep up with the low carbing since it seems ti change the paradigm.
There is evidence from old studies that suggest that beta cell output in T2D does decrease which is why previous generations progressed to insulin therapy. We are in recent times seeing this trend being slowed and maybe even reversed by new interventions and medications. So the jury appears to be out on this. The Newcastle Diet study suggests that ectopic fat buildup in the pancreas is responsible for the deterioration, but IMO that is oversimplistic and that there are other factors at play such as Insulin resisance. There is also a theory that beta cells change into alpha cells (de-differentiation) and stop producing insulin. So far there is no evidence to support this theory, and it it were true then the cells would be working in a way that does not occur in any other body cells.
So my answer to the OP is a possible maybe., or even a logical perhaps but my advice is to kep up with the low carbing since it seems ti change the paradigm.
