Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Diabetes Discussion
Diabetes Discussions
Does fatty acid oxidation reduce or increase inflammation?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="ianf0ster" data-source="post: 2206833" data-attributes="member: 506169"><p>I haver seen a few of these mouse studies which appear to give results that aren't consistent with what appears to work for us (T2Diabetics).</p><p>Here is one that I commented on in 'the other forum':</p><p></p><p>Another member posted:</p><p>"A ketogenic diet -- which provides 99% of calories from fat and only 1% from carbohydrates -- produces health benefits in the short term, but negative effects after about a week, Yale researchers found in a study of mice.</p><p></p><p>The results offer early indications that the keto diet could, over limited time periods, improve human health by lowering diabetes risk and inflammation. They also represent an important first step toward possible clinical trials in humans.</p><p></p><p>The keto diet has become increasingly popular as celebrities, including Gwyneth Paltrow, Lebron James, and Kim Kardashian, have touted it as a weight-loss regimen.</p><p></p><p><a href="https://www.sciencedaily.com/releases/2020/01/200127134741.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29" target="_blank">https://www.sciencedaily.com/releases/2020/01/200127134741.htm</a> "</p><p></p><p>I replied:</p><p>I quote the relevant part of this and bold the key phrases, the rather strange parts I put in italics:</p><p></p><p>"A keto diet tricks the body into burning fat, said lead author Vishwa Deep Dixit of the Yale School of Medicine. When the body's glucose level is reduced due to the diet's low carbohydrate content, the body acts as if it is in a starvation state -- although it is not -- and begins burning fats instead of carbohydrates. This process in turn yields chemicals called ketone bodies as an alternative source of fuel. <strong>When the body burns ketone bodies, tissue-protective gamma delta T-cells expand throughout the body.</strong></p><p></p><p><strong>This reduces diabetes risk and inflammation, and improves the body's metabolism,</strong> said Dixit, the Waldemar Von Zedtwitz Professor of Comparative Medicine and of Immunobiology. <strong>After a week on the keto diet, he said, mice show a reduction in blood sugar levels and inflammation.</strong></p><p></p><p><strong><em>But when the body is in this "starving-not-starving" mode, fat storage is also happening simultaneously with fat breakdown</em></strong>, the researchers found. <strong><em>When mice continue to eat the high-fat, low-carb diet beyond one week, Dixit said, they consume more fat than they can burn, and develop diabetes and obesity.</em></strong>"</p><p></p><p>My comments / questions:</p><p>It is important to note that where 'diabetes' is mentioned, it really should be saying Type 2 Diabetes - since this doesn't apply to other forms such as Type 1.</p><p><span style="color: #0000ff">1. We do know that it is possible to over-eat when on a Keto 'Way Of Eating'. But surely this isn't possible on a Keto diet - the word diet implying a calorie restriction!</span></p><p><span style="color: #0000ff">2. Do mice exhibit that same satiety controls such as humans and cats, or do they lack them as in dogs and bears? If they lack the satiety controls, then the 'continuing to eat high-fat, low-carb' portion of the text shows that the experiment was <strong>designed </strong>to show a poor longer-term result.</span></p><p><span style="color: #0000ff">3. Do natural mice develop diabetes from eating fats - or is this just because the lab mice are genetically altered to be susceptible to diabetes?</span></p><p><span style="color: #0000ff">4. Is there any evidence that humans ever develop type 2 diabetes from eating fat without carbs? All the evidence I see shows that it is due to carbohydrates.</span></p><p><span style="color: #0000ff">How do you develop Insulin Resistance by eating something that lowers your Insulin? Do people with allergies get worse by avoiding that to which they are allergic to?</span></p></blockquote><p></p>
[QUOTE="ianf0ster, post: 2206833, member: 506169"] I haver seen a few of these mouse studies which appear to give results that aren't consistent with what appears to work for us (T2Diabetics). Here is one that I commented on in 'the other forum': Another member posted: "A ketogenic diet -- which provides 99% of calories from fat and only 1% from carbohydrates -- produces health benefits in the short term, but negative effects after about a week, Yale researchers found in a study of mice. The results offer early indications that the keto diet could, over limited time periods, improve human health by lowering diabetes risk and inflammation. They also represent an important first step toward possible clinical trials in humans. The keto diet has become increasingly popular as celebrities, including Gwyneth Paltrow, Lebron James, and Kim Kardashian, have touted it as a weight-loss regimen. [URL='https://www.sciencedaily.com/releases/2020/01/200127134741.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fdiabetes+%28Diabetes+News+--+ScienceDaily%29']https://www.sciencedaily.com/releases/2020/01/200127134741.htm[/URL] " I replied: I quote the relevant part of this and bold the key phrases, the rather strange parts I put in italics: "A keto diet tricks the body into burning fat, said lead author Vishwa Deep Dixit of the Yale School of Medicine. When the body's glucose level is reduced due to the diet's low carbohydrate content, the body acts as if it is in a starvation state -- although it is not -- and begins burning fats instead of carbohydrates. This process in turn yields chemicals called ketone bodies as an alternative source of fuel. [B]When the body burns ketone bodies, tissue-protective gamma delta T-cells expand throughout the body.[/B] [B]This reduces diabetes risk and inflammation, and improves the body's metabolism,[/B] said Dixit, the Waldemar Von Zedtwitz Professor of Comparative Medicine and of Immunobiology. [B]After a week on the keto diet, he said, mice show a reduction in blood sugar levels and inflammation.[/B] [B][I]But when the body is in this "starving-not-starving" mode, fat storage is also happening simultaneously with fat breakdown[/I][/B], the researchers found. [B][I]When mice continue to eat the high-fat, low-carb diet beyond one week, Dixit said, they consume more fat than they can burn, and develop diabetes and obesity.[/I][/B]" My comments / questions: It is important to note that where 'diabetes' is mentioned, it really should be saying Type 2 Diabetes - since this doesn't apply to other forms such as Type 1. [COLOR=#0000ff]1. We do know that it is possible to over-eat when on a Keto 'Way Of Eating'. But surely this isn't possible on a Keto diet - the word diet implying a calorie restriction! 2. Do mice exhibit that same satiety controls such as humans and cats, or do they lack them as in dogs and bears? If they lack the satiety controls, then the 'continuing to eat high-fat, low-carb' portion of the text shows that the experiment was [B]designed [/B]to show a poor longer-term result. 3. Do natural mice develop diabetes from eating fats - or is this just because the lab mice are genetically altered to be susceptible to diabetes? 4. Is there any evidence that humans ever develop type 2 diabetes from eating fat without carbs? All the evidence I see shows that it is due to carbohydrates. How do you develop Insulin Resistance by eating something that lowers your Insulin? Do people with allergies get worse by avoiding that to which they are allergic to?[/COLOR] [/QUOTE]
Verification
Post Reply
Home
Forums
Diabetes Discussion
Diabetes Discussions
Does fatty acid oxidation reduce or increase inflammation?
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…