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EUCREAS

B

Bluenosesol

Well-Known Member
Messages
446
Location
Solihull, West Midlands
Type of diabetes
Type 2
Treatment type
Diet only
Dislikes
Dark mornings, intolerance any one with a superiority complex...
Folks,

whilst mooching on the Net, I came across a new drug referred to as Eucreas. Apparently its a combination of Metformin and Vildagliptin and as a combo, they are supposed to achieve a 1.1 mmol reduction in HBA1C as opposed to taking Metformin alone.
If its in common use, I would like to ask my DN about it.

WIKI states ..
Vildagliptin (previously identified as LAF237, trade name Galvus) is a new oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1[2][3] and GIP[3] by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas.

Vildagliptin has been shown to reduce hyperglycemia in type 2 diabetes mellitus.[2]

Apparently approved in EU but not in US.

Regards Steve.
 
Hi Steve.

Eucreas is not new. Neither is Vildagliptin. It is not commonly prescribed because it costs around £32 per 60 tabs nett !! So don't get your hopes up ? Metformin is far cheaper.

They have been in use for quite some time, Eucreas is manufactured by Novartis and there are also generic versions. As you say a combi drug, Vildagliptin and Metformin. It is sometimes prescribed when Metformin alone is not controlling Bg levels adequately. Rather than up the dose of Met they just add the Vildagliptin without you having to take an additional tablet.

So it does increase the effect, however, if you are not on the max dose of Met and you have no problems just get a higher dose of that. At the max dose Met will typically reduce Bg numbers by around 1-2 points. Diet changes also make it work more effectively.

As to how muich it affects your HbA1c, couldnt say. Any decrease in your overall numbers will show up in a HbA1c test.
 
Hi Cugila,

I was prescribed Eucreas 12 days ago on my initial diagnosis.
I live in Greece and the cost is 130 Euros for 60 x 50mg tablets.
Obviously being new I am unaware of the benifits compared to other medication.

BG now down to 7.3 from 16.7

Allan
 
For ME, the favourite strategy is to control what I eat and use LESS medicine
Hana
 
Hana,

I understand the desire to reduce and move away from medication as it then provides confidence that ones self is doing the work and keeping progression or the need for insulin at bay.
However, I have read much comment that T2's at least should take metformin regardless of level of control because it preserves beta cells and reduces, stops or even improves the damage to blood vessels. The restriction of glucose dumping by the liver is also cited as positive.

I am no authority on the matter though, I must admit.

Steve.
 
Steve I do use Metformin. 2 x 500mg per day and I'm aware that it does confer a number of protections. However, It's the only thing I'm prepared to use. I did a little trial a while back and I CAN do without it.
Hana
 
Hana,

you are reading my mind!... my thoughts exactly. If my DN asks me to reduce to 0 metformin (last review I reduced from 2 x 500 to 1 x 500) I might ask her if I can stay on 500g and then trial for a month.

Steve.
 
i moved to Eucreas from Avandia 3 months ago. I was getting weight gain with avandia, about 1lb per week on a 1700cal per day diet. (carbs were what carbs were, some days low, some days not) I am sedentary due to chronic back and joint problems.

So now I have stopped putting weight on, but by BG (with meter) has gone up about 2 points. Not happy about that, but happy about not putting weight on. new hba1c test done friday, get results later this week.

We shall see.
 
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