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Evidence for kidney protection from Lisinopril
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<blockquote data-quote="phoenix" data-source="post: 576924" data-attributes="member: 12578"><p>Cochrane</p><p>This systematic review aimed to assess the benefits and harms of blood pressure lowering agents in people with diabetes mellitus and a normal amount of albumin in the urine (normoalbuminuria) Fairly detailed summary but full text behind paywall.</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004136.pub3/abstract;jsessionid=5C612ADBAAA17ED4139ECF20E10C69EB.f03t04" target="_blank">http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004136.pub3/abstract;jsessionid=5C612ADBAAA17ED4139ECF20E10C69EB.f03t04</a></p><p> </p><p>If you have microalbuminuria then there is strong evidence that it delays progression to macroalbuminuria</p><p>'In some studies, the beneficial effect of ACE inhibitors or ARBs appeared greater than the difference in mean follow-up blood pressure or persisted after adjustment for follow-up blood pressure in multiple regression analysis,<strong> suggesting that the benefit is due to mechanisms in addition to the antihypertensive</strong> effect.'</p><p><a href="https://www.kidney.org/professionals/kdoqi/guidelines_bp/guide_8.htm" target="_blank">https://www.kidney.org/professionals/kdoqi/guidelines_bp/guide_8.htm</a></p></blockquote><p></p>
[QUOTE="phoenix, post: 576924, member: 12578"] Cochrane This systematic review aimed to assess the benefits and harms of blood pressure lowering agents in people with diabetes mellitus and a normal amount of albumin in the urine (normoalbuminuria) Fairly detailed summary but full text behind paywall. [url]http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004136.pub3/abstract;jsessionid=5C612ADBAAA17ED4139ECF20E10C69EB.f03t04[/url] If you have microalbuminuria then there is strong evidence that it delays progression to macroalbuminuria 'In some studies, the beneficial effect of ACE inhibitors or ARBs appeared greater than the difference in mean follow-up blood pressure or persisted after adjustment for follow-up blood pressure in multiple regression analysis,[B] suggesting that the benefit is due to mechanisms in addition to the antihypertensive[/B] effect.' [url]https://www.kidney.org/professionals/kdoqi/guidelines_bp/guide_8.htm[/url] [/QUOTE]
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