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Exogenous ketones

EllieM said:
Hmm, any ideas what units they are using for the blood glucose?

and decreased mean blood glucose (MD = –0.54 mM; 95% CI: –0.68, –0.40 mM; P < 0.001).
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Nope. Beats me but I’m curious
 
OrsonKartt said:
Nope. Beats me but I’m curious
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Aha, google is my friend
The international standard way of measuring blood glucose levels is in terms of a molar concentration, measured in mmol/L (millimoles per litre or millimolar, abbreviated mM).

So that's a drop of maybe 0.5 mmol/L in the (meta) study....
 
No but I eat a low carb ketogenic diet to do this.

My (non scientific!) understanding is that we preferentially burn carbs which are converted to glucose for fuel resulting in potentially high glucose levels, then any dietary fat and finally stored fat both converted to fatty acids/ketones (? β-hydroxybutyrate) which won't increase glucose. So if we eat less carbs replacing them with more fat the less glucose gets generated and levels will come down. Apparently exogenous ketones can aid the initial transition to ketosis and fat burning mode as our bodies don't have then to re-learn how to do the initial fat to ketones conversions.
 
OrsonKartt said:
Anyone taking ketones to lower blood glucose?


https://academic.oup.com/advances/a...6/6563605?redirectedFrom=fulltext&login=false
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Last time I looked into this I discovered it is a good way of creating expensive wee. Our bodies can burn lipid fat (fatty acids) under low glucose conditions, but this produces ketones as a by producr that we excrete in our breath, sweat, and wee. Exogenous ketones pass through our system to the exit without doing much. There was a celeb diet fad called Raspberry Ketones that hit the headlines, and if you replaced normal food intake then it gave weight loss but only because it was otherwise poor nutritiom.
 
According to the Randle Cycle (the lipid equivalent of the Krebs or Citric Cycle) the body burns lipid fat in the form of fatty acids, This oxidation of the fatty acids creates fragments of FA in the form of ketones. It is the oxidation of fatty acids that creates the ketones. Then the ketones can cross the brain barrier (which lipids can't) and be used by the brain instead of glucose. This has been proven by feeding alzheiners patients ketone supplements that carry a radioactive tracer and then using MRI to see which lobes glow in the dark. My late wife had this procedure during her Parkinsons DX. So ketones are a secondary fuel which is why it is usually excreted. In other words, a diet consisting only of ketones would not sustain life as we know it. Man cannot live by supplements alone.
 
Someone at my wife's church has an MLM dealership and sells Raspberry Ketone supplements. She tried very hard to sell some to my wife to cure her Parkinsons, and then to me to cure my T2D and then to my son who had a DX of cancer. We declined all these special offers, and so we will never know if things would have changed. My wife sadly passed from Parkinsons complications and my son got married last month and is in full remission. I am still T2D.

Recent research does show some promise for Alzheimers patients but very limited. This may read across if they can show that alzheimers is indeed related to diabetes. (some call it the IR of the brain which is rubbish since insulin does not cross the blood brain barrier.)
 

My reason for asking is an on going desire to keep my glucose levels down ( of course). I’ve been low carb / keto for 4/5 yrs ( eggs / fish meat and a few veg) and have a hba1c of 43. I’ve never needed to loose weight (bmi =20) . Im still experimenting . Thanks for your thoughts
 
No probs. I experiment too. But this one has the appearance of a Turkey. As stated, the 0.5 mmol/l effect is about the same as Metformin on full dose. so not impressive. Certainly not at the prices they are charging for it. Save money, bath with a friend.
 
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