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Fasting for Autophagy
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<blockquote data-quote="kokhongw" data-source="post: 1722986" data-attributes="member: 277199"><p>Back in 2014 Valter Longo published a study that shows that fasting triggers stem cells regeneration</p><p><a href="https://news.usc.edu/63669/fasting-triggers-stem-cell-regeneration-of-damaged-old-immune-system/" target="_blank">https://news.usc.edu/63669/fasting-triggers-stem-cell-regeneration-of-damaged-old-immune-system/</a></p><p></p><p><span style="font-size: 15px"><strong>Fasting cycles</strong></span></p><p>Prolonged fasting forces the body to use stores of glucose, fat and ketones, but it also breaks down a significant portion of white blood cells. Longo likens the effect to lightening a plane of excess cargo.</p><p></p><p>During each cycle of fasting, this depletion of white blood cells induces changes that trigger stem cell-based regeneration of new immune system cells. In particular, prolonged fasting reduced the enzyme PKA, an effect previously discovered by the Longo team to extend longevity in simple organisms and which has been linked in other research to the regulation of stem cell self-renewal and pluripotency — that is, the potential for one cell to develop into many different cell types. Prolonged fasting also lowered levels of IGF-1, a growth-factor hormone that Longo and others have linked to aging, tumor progression and <a href="http://universityofsoutherncalifornia.cmail2.com/t/j-l-iikdhkd-iydddrfu-a/" target="_blank">cancer risk</a>.</p><p></p><p>“PKA is the key gene that needs to shut down in order for these stem cells to switch into regenerative mode. It gives the OK for stem cells to go ahead and begin proliferating and rebuild the entire system,” explained Longo, noting the potential of clinical applications that mimic the effects of prolonged fasting to rejuvenate the immune system. “And the good news is that the body got rid of the parts of the system that might be damaged or old, the inefficient parts, during the fasting. Now, if you start with a system heavily damaged by chemotherapy or aging, fasting cycles can generate, literally, a new immune system.”</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102383/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102383/</a></p></blockquote><p></p>
[QUOTE="kokhongw, post: 1722986, member: 277199"] Back in 2014 Valter Longo published a study that shows that fasting triggers stem cells regeneration [URL]https://news.usc.edu/63669/fasting-triggers-stem-cell-regeneration-of-damaged-old-immune-system/[/URL] [SIZE=4][B]Fasting cycles[/B][/SIZE] Prolonged fasting forces the body to use stores of glucose, fat and ketones, but it also breaks down a significant portion of white blood cells. Longo likens the effect to lightening a plane of excess cargo. During each cycle of fasting, this depletion of white blood cells induces changes that trigger stem cell-based regeneration of new immune system cells. In particular, prolonged fasting reduced the enzyme PKA, an effect previously discovered by the Longo team to extend longevity in simple organisms and which has been linked in other research to the regulation of stem cell self-renewal and pluripotency — that is, the potential for one cell to develop into many different cell types. Prolonged fasting also lowered levels of IGF-1, a growth-factor hormone that Longo and others have linked to aging, tumor progression and [URL='http://universityofsoutherncalifornia.cmail2.com/t/j-l-iikdhkd-iydddrfu-a/']cancer risk[/URL]. “PKA is the key gene that needs to shut down in order for these stem cells to switch into regenerative mode. It gives the OK for stem cells to go ahead and begin proliferating and rebuild the entire system,” explained Longo, noting the potential of clinical applications that mimic the effects of prolonged fasting to rejuvenate the immune system. “And the good news is that the body got rid of the parts of the system that might be damaged or old, the inefficient parts, during the fasting. Now, if you start with a system heavily damaged by chemotherapy or aging, fasting cycles can generate, literally, a new immune system.” [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102383/[/URL] [/QUOTE]
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