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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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<blockquote data-quote="Steve14" data-source="post: 1397866" data-attributes="member: 305713"><p>Here is the article: <a href="http://www.bbc.com/news/health-39070183" target="_blank">link</a></p><p><a href="http://www.bbc.com/news/health-39070183" target="_blank"></a></p><p>And here is the peer-reviewed journal: <a href="http://www.cell.com/cell/fulltext/S0092-8674(17)30130-7" target="_blank">link</a></p><p></p><p>To summarize it:</p><p></p><p>- <strong>FMD </strong>(fasting mimicking diet) first <strong>reduces β-cell number</strong>, but <strong>then it returns to normal </strong>levels <strong>after re-feeding</strong>, <em>"suggesting an in vivo lineage reprogramming."</em></p><p></p><p>- <strong>FMD </strong>as a <strong>low protein</strong>, <strong>low sugar </strong>cyclic <strong>diet </strong>used in the study.</p><p></p><p>- <strong>FMD </strong>cycle <strong>suppressed cytokine production associated with β-cell damage</strong>, and <strong>increased the number of cytokines associated with β-cell regeneration</strong>.</p><p><em>"...FMD cycles reduce inflammation and promote changes in the levels of cytokines and other proteins, which may be beneficial for the restoration of insulin secretion and the reversal of hyperglycemia."</em></p><p></p><p>- (after comparing healthy human vs T1D cultured pancreatic islets) <em>"...<strong>These results raise the possibility </strong>that the effect of the <strong>FMD </strong>on <strong>pancreatic regeneration in T1D subjects </strong>could <strong>be mimicked or enhanced </strong>by <strong>pharmacological inhibition of these pathways</strong>."</em></p><p></p><p>So this isn't a magic bullet for type 1-s, but with applied diet AND/OR shutting down the mTOR and PKA pathway (with medication), this could be successful. Now the good news is that we have inhibitor drugs for them.</p><p></p><p>Thoughts?</p></blockquote><p></p>
[QUOTE="Steve14, post: 1397866, member: 305713"] Here is the article: [URL='http://www.bbc.com/news/health-39070183']link [/URL] And here is the peer-reviewed journal: [URL='http://www.cell.com/cell/fulltext/S0092-8674(17)30130-7']link[/URL] To summarize it: - [B]FMD [/B](fasting mimicking diet) first [B]reduces β-cell number[/B], but [B]then it returns to normal [/B]levels [B]after re-feeding[/B], [I]"suggesting an in vivo lineage reprogramming."[/I] - [B]FMD [/B]as a [B]low protein[/B], [B]low sugar [/B]cyclic [B]diet [/B]used in the study. - [B]FMD [/B]cycle [B]suppressed cytokine production associated with β-cell damage[/B], and [B]increased the number of cytokines associated with β-cell regeneration[/B]. [I]"...FMD cycles reduce inflammation and promote changes in the levels of cytokines and other proteins, which may be beneficial for the restoration of insulin secretion and the reversal of hyperglycemia."[/I] - (after comparing healthy human vs T1D cultured pancreatic islets) [I]"...[B]These results raise the possibility [/B]that the effect of the [B]FMD [/B]on [B]pancreatic regeneration in T1D subjects [/B]could [B]be mimicked or enhanced [/B]by [B]pharmacological inhibition of these pathways[/B]."[/I] So this isn't a magic bullet for type 1-s, but with applied diet AND/OR shutting down the mTOR and PKA pathway (with medication), this could be successful. Now the good news is that we have inhibitor drugs for them. Thoughts? [/QUOTE]
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