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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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<blockquote data-quote="Hoping4Cure" data-source="post: 1441469" data-attributes="member: 393050"><p>I can't get over how I've gotten my disease management goals all wrong this whole time. That link is a game-changer for my manic fixation on achieving a super low A1C. It is much better to use much less insulin daily than have an A1C in the right zone, if I want to live long. Totally flips my entire strategy backwards. And made me just do a 180 in terms of stopping verapamil, which protects beta cells against glucotoxicity. If my goal is to restore beta cell mass and function, then it seems counterproductive to allow myself a much more lax A1C target (and consequently less testing and less insulin taken per day) and stop verapamil at the same time.</p><p></p><p>I have to thank this website for exposing me to some new ideas, which I might never have discovered. It's good to shake things up. I'm cutting my insulin in half immediately, and won't make any corrections unless my BG is higher than 10. Bernstein was right all along it turns out. (he suggests in his book never making corrections due to incorrect insulin-to-carb estimates, but adjusting it slightly for the next meal). I'm going to have to unlearn being such a manic and frequent tester. My health should get better with less insulin TDD, due to reduced insulin resistance which I presume may type 1s have. Then I can focus on the benefits of caloric restriction + fasting + regen side of things. If I want to lower my A1C in the future, I'll do it by lowering daily calories, not by taking more insulin.</p></blockquote><p></p>
[QUOTE="Hoping4Cure, post: 1441469, member: 393050"] I can't get over how I've gotten my disease management goals all wrong this whole time. That link is a game-changer for my manic fixation on achieving a super low A1C. It is much better to use much less insulin daily than have an A1C in the right zone, if I want to live long. Totally flips my entire strategy backwards. And made me just do a 180 in terms of stopping verapamil, which protects beta cells against glucotoxicity. If my goal is to restore beta cell mass and function, then it seems counterproductive to allow myself a much more lax A1C target (and consequently less testing and less insulin taken per day) and stop verapamil at the same time. I have to thank this website for exposing me to some new ideas, which I might never have discovered. It's good to shake things up. I'm cutting my insulin in half immediately, and won't make any corrections unless my BG is higher than 10. Bernstein was right all along it turns out. (he suggests in his book never making corrections due to incorrect insulin-to-carb estimates, but adjusting it slightly for the next meal). I'm going to have to unlearn being such a manic and frequent tester. My health should get better with less insulin TDD, due to reduced insulin resistance which I presume may type 1s have. Then I can focus on the benefits of caloric restriction + fasting + regen side of things. If I want to lower my A1C in the future, I'll do it by lowering daily calories, not by taking more insulin. [/QUOTE]
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