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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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<blockquote data-quote="mark2" data-source="post: 1449970" data-attributes="member: 352072"><p>I've been doing this too, I finished my second round of fasting on Sunday. </p><p>I'm not sure that my first round really counts as I had to exceed the limits of the FMD to add sugars to correct my BG. So the first round was more of a trial run really. I also did a 48 hours stint in March to see how I coped.</p><p>I think this is quite tricky for us T1s and I wouldn't advise anyone else to try it without supervision, as previously stated by Dr Longo.</p><p></p><p>I found that my daily insulin requirement fell steeply over the fast, so adjusting the basal dose could be quite tricky. I also experienced quite high ketone levels at the end of the fast (6 mmol/L), which was was uncomfortable. It's certainly seems unusual to have a combination of high ketones from lack of insulin and low blood sugar at the same time! It's easy to see how this could escalate and develop into ketoacidosis.</p><p></p><p>I'm have CGM, and I've been monitoring my ketone level 2 or 3 times a day during the fast using a Freestyle Neo reader. I've had tests for IGF-1 (very low @ 59ng/mL ) and C-peptide (~nil) on day 2 of round 2 (should have been at the start, I know!), and IGF-1 and blood count on day 5 (no results back yet). I'll be having IGF-1 and C-peptide done again on Monday after 1 week of "refeeding"/ 1st day of round 3. </p><p>I'm highly sceptical, but I plan to keep this cycle of fasting testing going for another few rounds.</p></blockquote><p></p>
[QUOTE="mark2, post: 1449970, member: 352072"] I've been doing this too, I finished my second round of fasting on Sunday. I'm not sure that my first round really counts as I had to exceed the limits of the FMD to add sugars to correct my BG. So the first round was more of a trial run really. I also did a 48 hours stint in March to see how I coped. I think this is quite tricky for us T1s and I wouldn't advise anyone else to try it without supervision, as previously stated by Dr Longo. I found that my daily insulin requirement fell steeply over the fast, so adjusting the basal dose could be quite tricky. I also experienced quite high ketone levels at the end of the fast (6 mmol/L), which was was uncomfortable. It's certainly seems unusual to have a combination of high ketones from lack of insulin and low blood sugar at the same time! It's easy to see how this could escalate and develop into ketoacidosis. I'm have CGM, and I've been monitoring my ketone level 2 or 3 times a day during the fast using a Freestyle Neo reader. I've had tests for IGF-1 (very low @ 59ng/mL ) and C-peptide (~nil) on day 2 of round 2 (should have been at the start, I know!), and IGF-1 and blood count on day 5 (no results back yet). I'll be having IGF-1 and C-peptide done again on Monday after 1 week of "refeeding"/ 1st day of round 3. I'm highly sceptical, but I plan to keep this cycle of fasting testing going for another few rounds. [/QUOTE]
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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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