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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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<blockquote data-quote="Mr Whippy" data-source="post: 1473745" data-attributes="member: 28538"><p>Latest update ----</p><p></p><p>Finished fast #3 and the "re-feed" - I have a slight improvement in basal insulin requirements over fast #1 but not much...</p><p>I have written off fast #2 as a failure due to overdoing the protein (see my earlier posts)</p><p></p><p>Re. the experience of the FMD itself, I generally find that days 1 & 2 are not too bad and I go into keto around lunchtime on day 2.</p><p>Days 3 & 4 are a miserable grind, hard work, I can't concentrate as well and I do tend to be grumpy.</p><p>The last session I felt much better on day 5, clearer head and not grumpy, but still hungry. (probably just my body becoming used to the keto.)</p><p></p><p>I have also been having a little salt with my avocados (it does improve the flavour) and a few drops of balsamic vinegar on my small green salad - likewise.</p><p></p><p>As you will see by my basal rate chart below, I have gained another reduction in insulin required, although it is much less than that achieved on my 1st FMD. I didn't bother charting results of FMD #2 as they were so small as to be negligible on the graph.</p><p></p><p></p><p><a href="http://s71.photobucket.com/user/newlancsvwclub/media/Diabetes/Basal%2028-5-17.jpg.html" target="_blank"><img src="http://i71.photobucket.com/albums/i143/newlancsvwclub/Diabetes/Basal%2028-5-17.jpg" alt="" class="fr-fic fr-dii fr-draggable " style="" /></a></p><p></p><p>Now it could be that my first session also lost me some visceral fat, which helped sensitivity, which would account for a better result for session 1 than subsequent sessions, or quite possibly any number of other reasons. Without proper blood tests before and after it's impossible to say for sure exactly what's going on. However, it's still a gain so I will continue - my FMD#4 starts tomorrow.</p><p></p><p>One other difference between my first and last sessions was that, once keto had kicked in at lunchtime on day 2, on session 1 I ran a temporary basal level of 30% of my pre fast level until breaking the fast on morning of day 6. My BG's kept a pretty flat line around 6 to 7 mmoL during the keto phase.</p><p></p><p>The last session (for the keto phase) I ran a lot less insulin, basically just my early morning "spike" with most of the rest of the day at zero - and my BG levels ran at a pretty steady 9 to 10 mmoL</p><p></p><p>So this time I will try a 30% basal rate again during keto, and aim to hold my BG's around 6 mmoL - see if that makes a difference. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p><p></p><p>Going to see my consultant in a couple of weeks - I will ask for a C peptide test but it's all down to NHS budgets....</p><p></p><p> Cheers - Dave.</p></blockquote><p></p>
[QUOTE="Mr Whippy, post: 1473745, member: 28538"] Latest update ---- Finished fast #3 and the "re-feed" - I have a slight improvement in basal insulin requirements over fast #1 but not much... I have written off fast #2 as a failure due to overdoing the protein (see my earlier posts) Re. the experience of the FMD itself, I generally find that days 1 & 2 are not too bad and I go into keto around lunchtime on day 2. Days 3 & 4 are a miserable grind, hard work, I can't concentrate as well and I do tend to be grumpy. The last session I felt much better on day 5, clearer head and not grumpy, but still hungry. (probably just my body becoming used to the keto.) I have also been having a little salt with my avocados (it does improve the flavour) and a few drops of balsamic vinegar on my small green salad - likewise. As you will see by my basal rate chart below, I have gained another reduction in insulin required, although it is much less than that achieved on my 1st FMD. I didn't bother charting results of FMD #2 as they were so small as to be negligible on the graph. [URL='http://s71.photobucket.com/user/newlancsvwclub/media/Diabetes/Basal%2028-5-17.jpg.html'][IMG]http://i71.photobucket.com/albums/i143/newlancsvwclub/Diabetes/Basal%2028-5-17.jpg[/IMG][/URL] Now it could be that my first session also lost me some visceral fat, which helped sensitivity, which would account for a better result for session 1 than subsequent sessions, or quite possibly any number of other reasons. Without proper blood tests before and after it's impossible to say for sure exactly what's going on. However, it's still a gain so I will continue - my FMD#4 starts tomorrow. One other difference between my first and last sessions was that, once keto had kicked in at lunchtime on day 2, on session 1 I ran a temporary basal level of 30% of my pre fast level until breaking the fast on morning of day 6. My BG's kept a pretty flat line around 6 to 7 mmoL during the keto phase. The last session (for the keto phase) I ran a lot less insulin, basically just my early morning "spike" with most of the rest of the day at zero - and my BG levels ran at a pretty steady 9 to 10 mmoL So this time I will try a 30% basal rate again during keto, and aim to hold my BG's around 6 mmoL - see if that makes a difference. :) Going to see my consultant in a couple of weeks - I will ask for a C peptide test but it's all down to NHS budgets.... Cheers - Dave. [/QUOTE]
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