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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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<blockquote data-quote="Hoping4Cure" data-source="post: 1839531" data-attributes="member: 393050"><p>I would also recommend checking antibody levels. I worry that antibody levels might have gone up instead of down! I did FMD about ten times last year and my c-peptide levels dropped by 50%. </p><p></p><p>I have a few ideas why this may have happened:</p><p></p><p>1) I lost my insurance for GLP-1, which is a known beta cell regen agent, and glucagon suppressor.</p><p>2) Too aggressively re-feeding and leaving ketosis. I think it's better to stay in ketosis, fasting or not, and just vary the overall daily calories and protein levels to go into protection / trigger regeneration ready state, then activate IGF-1 with protein and only moderate carb increase. Avoid carb binging! Very, very bad. </p><p>3) Low carb tolerance and lowered insulin sensitivity, meant I had higher sugars when not fasting. It was a nightmare, really uncomfortable. This is why I stopped.</p><p>4) You must exercise aggressively to maintain decent insulin sensitivity. I did not do this, as I was busy with life and work and had lost tons of weight too.</p><p></p><p>So FMD is counterproductive for type 1s, or could work in the right conditions, but you still need to avoid carbs even during the first feast, and you certainly shouldn't stop taking GLP-1 which is a wonder drug. I'm back on it now, if my next c-peptide is higher I know 100% it's because of that and that alone. My sugars are great again now on Ozempic (1/week GLP1), and insulin TDD is much lower than last year. </p><p></p><p>I'm trying to find out if the keto variant of FMD is suitable for those of us who don't want so many carbs, even when we are starving. The best way to avoid stressing beta cells too much is to not give them too much work at a time. So re-feeding is potentially what killed off a lot of my beta cells last year, or maybe my immune system was actually invigorated which increased my antibodies (don't think this, but it's a possibility), or maybe just having hyperglycemia due to low insulin sensitivity is what happens any time you leave ketosis anyway so this isn't news. Maybe I should ask the keto subforum about that point. It just seems weird that I'd need more insulin rather than less, each time I re-fed myself. Extremely frustrating experience, but maybe a learning opportunity. I forwarded all my notes and observations on the matter to Dr Longo's team, to see if there's some rationale to this lowered insulin sensitivity issue or if this is a discovery. Even negative discoveries can help illuminate the right way forward.</p></blockquote><p></p>
[QUOTE="Hoping4Cure, post: 1839531, member: 393050"] I would also recommend checking antibody levels. I worry that antibody levels might have gone up instead of down! I did FMD about ten times last year and my c-peptide levels dropped by 50%. I have a few ideas why this may have happened: 1) I lost my insurance for GLP-1, which is a known beta cell regen agent, and glucagon suppressor. 2) Too aggressively re-feeding and leaving ketosis. I think it's better to stay in ketosis, fasting or not, and just vary the overall daily calories and protein levels to go into protection / trigger regeneration ready state, then activate IGF-1 with protein and only moderate carb increase. Avoid carb binging! Very, very bad. 3) Low carb tolerance and lowered insulin sensitivity, meant I had higher sugars when not fasting. It was a nightmare, really uncomfortable. This is why I stopped. 4) You must exercise aggressively to maintain decent insulin sensitivity. I did not do this, as I was busy with life and work and had lost tons of weight too. So FMD is counterproductive for type 1s, or could work in the right conditions, but you still need to avoid carbs even during the first feast, and you certainly shouldn't stop taking GLP-1 which is a wonder drug. I'm back on it now, if my next c-peptide is higher I know 100% it's because of that and that alone. My sugars are great again now on Ozempic (1/week GLP1), and insulin TDD is much lower than last year. I'm trying to find out if the keto variant of FMD is suitable for those of us who don't want so many carbs, even when we are starving. The best way to avoid stressing beta cells too much is to not give them too much work at a time. So re-feeding is potentially what killed off a lot of my beta cells last year, or maybe my immune system was actually invigorated which increased my antibodies (don't think this, but it's a possibility), or maybe just having hyperglycemia due to low insulin sensitivity is what happens any time you leave ketosis anyway so this isn't news. Maybe I should ask the keto subforum about that point. It just seems weird that I'd need more insulin rather than less, each time I re-fed myself. Extremely frustrating experience, but maybe a learning opportunity. I forwarded all my notes and observations on the matter to Dr Longo's team, to see if there's some rationale to this lowered insulin sensitivity issue or if this is a discovery. Even negative discoveries can help illuminate the right way forward. [/QUOTE]
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