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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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<blockquote data-quote="Hoping4Cure" data-source="post: 1840273" data-attributes="member: 393050"><p>Well I remember binging on carbs the very first meal since I was absolutely starving by the end (I usually didn't eat anything at all the last 24 hours to really drive the regeneration signals home). That was a big mistake. I'm talking indian curry with naan bread galore, or even pizza. Ouch, my toes hurt even thinking about it. Super elevated sugars for many hours after eating, no matter how much insulin I took.</p><p></p><p>I'll share the team's responses when I get some. I don't know if what they'll say will be 100% restricted to type 1s, probably not. </p><p></p><p>But I would say, yes, when re-feeding just increase overall calories back to normal slowly, over 2 days minimum (4 would be better), and mix in cardio exercise to maintain sensitivity, but keep carbs relatively low all the time and definitely don't binge, no matter the temptation of a treat waiting for you on the finish line. Even a low-carb diet places more demand on type 1's beta cells than we can manage without external insulin, so don't stress them too hard. IGF-1 should rise in response to higher % of protein after the fasting is over, even if you don't spike carbs. I think protein doesn't need to be too much lower than fat either, according to the videos on the subject about the conditions when protein gets converted into sugar. It happens much less when the body is in a catabolic state so being low carb is enough to keep elevated protein levels from spiking your blood sugar and insulin requirements. You do need some sugar for IGF-1 levels to rise for regeneration, and for rebuilding itself, in addition to protein going much higher, but I wouldn't worry about it too much. The important thing is managing insulin insensitivity which is the worst thing about FMD, at least for me.</p></blockquote><p></p>
[QUOTE="Hoping4Cure, post: 1840273, member: 393050"] Well I remember binging on carbs the very first meal since I was absolutely starving by the end (I usually didn't eat anything at all the last 24 hours to really drive the regeneration signals home). That was a big mistake. I'm talking indian curry with naan bread galore, or even pizza. Ouch, my toes hurt even thinking about it. Super elevated sugars for many hours after eating, no matter how much insulin I took. I'll share the team's responses when I get some. I don't know if what they'll say will be 100% restricted to type 1s, probably not. But I would say, yes, when re-feeding just increase overall calories back to normal slowly, over 2 days minimum (4 would be better), and mix in cardio exercise to maintain sensitivity, but keep carbs relatively low all the time and definitely don't binge, no matter the temptation of a treat waiting for you on the finish line. Even a low-carb diet places more demand on type 1's beta cells than we can manage without external insulin, so don't stress them too hard. IGF-1 should rise in response to higher % of protein after the fasting is over, even if you don't spike carbs. I think protein doesn't need to be too much lower than fat either, according to the videos on the subject about the conditions when protein gets converted into sugar. It happens much less when the body is in a catabolic state so being low carb is enough to keep elevated protein levels from spiking your blood sugar and insulin requirements. You do need some sugar for IGF-1 levels to rise for regeneration, and for rebuilding itself, in addition to protein going much higher, but I wouldn't worry about it too much. The important thing is managing insulin insensitivity which is the worst thing about FMD, at least for me. [/QUOTE]
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