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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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<blockquote data-quote="MikeFailBetter" data-source="post: 1906813" data-attributes="member: 493399"><p>Some of us have been discussing carbs during refeeding. Should we allow our blood sugars to be high? How much insulin?</p><p></p><p>Since I'm a newbie, I won't post a link, but point you to a recent article entitled</p><p><span style="font-size: 22px"><strong>Cells that change jobs to fight diabetes</strong></span></p><p></p><p></p><p style="margin-left: 20px">"Researchers at the University of Geneva (UNIGE) have succeeded in showing how part of the pancreatic α and δ cells, which usually produce other hormones, can take over from the damaged β cells by starting to produce insulin.</p> <p style="margin-left: 20px">...</p> <p style="margin-left: 20px">First hypothesis: hyperglycaemia. In transplanted but non-diabetic mice, whose β cells remain perfectly functional and do not have hyperglycaemia, some α cells of the graft began to produce insulin when the β cells died in the transplanted islets. Consequently, hyperglycaemia does not cause α cell reallocation. The cellular pancreatic environment surrounding the islets is not involved either</p> <p style="margin-left: 20px">.....</p> <p style="margin-left: 20px">the researchers blocked, in non-diabetic mice, the receptors located on α cells surface to detect the presence of insulin. Some of these α cells then began to produce insulin, indicating that insulin itself would act as a brake, preventing the reprogramming of α cells.</p> <p style="margin-left: 20px"></p><p>Could similar mechanism be taking place during refeeding in FMD? To me, the lessons of this are: take your minimal insulin during refeeding, allowing higher than usual glycemia at least some of the time.</p></blockquote><p></p>
[QUOTE="MikeFailBetter, post: 1906813, member: 493399"] Some of us have been discussing carbs during refeeding. Should we allow our blood sugars to be high? How much insulin? Since I'm a newbie, I won't post a link, but point you to a recent article entitled [SIZE=6][B]Cells that change jobs to fight diabetes[/B][/SIZE] [INDENT]"Researchers at the University of Geneva (UNIGE) have succeeded in showing how part of the pancreatic α and δ cells, which usually produce other hormones, can take over from the damaged β cells by starting to produce insulin. ... First hypothesis: hyperglycaemia. In transplanted but non-diabetic mice, whose β cells remain perfectly functional and do not have hyperglycaemia, some α cells of the graft began to produce insulin when the β cells died in the transplanted islets. Consequently, hyperglycaemia does not cause α cell reallocation. The cellular pancreatic environment surrounding the islets is not involved either ..... the researchers blocked, in non-diabetic mice, the receptors located on α cells surface to detect the presence of insulin. Some of these α cells then began to produce insulin, indicating that insulin itself would act as a brake, preventing the reprogramming of α cells. [/INDENT] Could similar mechanism be taking place during refeeding in FMD? To me, the lessons of this are: take your minimal insulin during refeeding, allowing higher than usual glycemia at least some of the time. [/QUOTE]
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