Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Diabetes Discussion
Diabetes Discussions
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="Hoping4Cure" data-source="post: 1917649" data-attributes="member: 393050"><p>That's interesting. But I think you still need to simply look at c-peptide levels before and after. I've checked mine again and again and my highest level was 0.51 in 2015 (on all kinds of drugs like GLP-1 and so on) and now it's 0.044. It's possible I didn't test scientifically enough using the same sugar challenge, or maybe my beta cells are just wiped. My anti-GAD is in the normal range for non-diabetics but I have no values for any other antibodies so I can't be sure what's killing off my beta cells now. I managed to boost them pretty high in 2015, close to half of what a normal person has (or even someone like Dan Darkes, who is probably still far from full up in terms of beta cell count, but past the finish line so he can manage without insulin shots given his regime). I eat pretty low carb and have an A1C of 6.1, which could be better but I don't have a CGM, any GLP-1 script, or a pump, so I'm doing OK I think all considering. I still want to try metformin and maybe will do another fasting cycle next spring, after I get fit from running. I had a foot ulcer which is healed now, thankfully. My buddy died and I coped by overeating for a couple days, that was enough to cause an ulcer in my big toe. Scary stuff but I'm back to being very rigorous. Sorry for the rambling post. I was so hopeful for FMD before but I don't think it will regenerate beta cells in type 1s, at least not fast enough to prevent them from being destroyed. Hyperglycemia is necessary to bring new beta cells to maturity aka fully functional to both detect blood sugar then release insulin in response, but if they're too stressed from constant hypers then that's bad too. I am 99% sure that my overconsumption of carbs during refeeding last year after my dozen or so FMD cycles (up to weekly, 4 days FMD 3 days feeding at one point), actually hurt my health more than helped it. I believe you need to simply boost protein and mild calorie uptake when refeeding to not over-do it. Anyway, that's my theory. I overdid it thinking that it would be really good to have high contrast between low-IGF-1 periods and high IGF-1 periods, but I think you can do that just fine with re-adding animal protein to your diet during refeeding and not blast your pancreas with sugar it can't handle. Trust me, if your sugars are above normal, even a little bit, whatever beta cells you have are already at their limit, pushing them further will only result in their demise. It's like pushing more on the gas when you have a near-empty tank and no coolant in the radiator. Take it easy and you'll go farther, I think.</p></blockquote><p></p>
[QUOTE="Hoping4Cure, post: 1917649, member: 393050"] That's interesting. But I think you still need to simply look at c-peptide levels before and after. I've checked mine again and again and my highest level was 0.51 in 2015 (on all kinds of drugs like GLP-1 and so on) and now it's 0.044. It's possible I didn't test scientifically enough using the same sugar challenge, or maybe my beta cells are just wiped. My anti-GAD is in the normal range for non-diabetics but I have no values for any other antibodies so I can't be sure what's killing off my beta cells now. I managed to boost them pretty high in 2015, close to half of what a normal person has (or even someone like Dan Darkes, who is probably still far from full up in terms of beta cell count, but past the finish line so he can manage without insulin shots given his regime). I eat pretty low carb and have an A1C of 6.1, which could be better but I don't have a CGM, any GLP-1 script, or a pump, so I'm doing OK I think all considering. I still want to try metformin and maybe will do another fasting cycle next spring, after I get fit from running. I had a foot ulcer which is healed now, thankfully. My buddy died and I coped by overeating for a couple days, that was enough to cause an ulcer in my big toe. Scary stuff but I'm back to being very rigorous. Sorry for the rambling post. I was so hopeful for FMD before but I don't think it will regenerate beta cells in type 1s, at least not fast enough to prevent them from being destroyed. Hyperglycemia is necessary to bring new beta cells to maturity aka fully functional to both detect blood sugar then release insulin in response, but if they're too stressed from constant hypers then that's bad too. I am 99% sure that my overconsumption of carbs during refeeding last year after my dozen or so FMD cycles (up to weekly, 4 days FMD 3 days feeding at one point), actually hurt my health more than helped it. I believe you need to simply boost protein and mild calorie uptake when refeeding to not over-do it. Anyway, that's my theory. I overdid it thinking that it would be really good to have high contrast between low-IGF-1 periods and high IGF-1 periods, but I think you can do that just fine with re-adding animal protein to your diet during refeeding and not blast your pancreas with sugar it can't handle. Trust me, if your sugars are above normal, even a little bit, whatever beta cells you have are already at their limit, pushing them further will only result in their demise. It's like pushing more on the gas when you have a near-empty tank and no coolant in the radiator. Take it easy and you'll go farther, I think. [/QUOTE]
Verification
Post Reply
Home
Forums
Diabetes Discussion
Diabetes Discussions
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…