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Fats and Insulin Resistance
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<blockquote data-quote="Sean_Raymond" data-source="post: 2352741" data-attributes="member: 403497"><p>This is a good point. We eat mixed meals with different macronutrients in different ratios so studies showing the effect of a particular nutrient doesn't necessarily mean this translates to what happens when we eat 'food'. A study I recently saw used fat boluses to show the effect of fat per se on insulin sensitivity reduction (in insulin sensitive subjects). Glycaemia wasn't affected in this study but that makes sense given no glucose was administered and we have non insulin dependent glucose transporters. This potential blunting of the body's response to insulin has also been shown using mixed meals with the effect increasing as the fat % of the meal is increased showing it occurred in the presence of glucose. I doubt the insulin blunting effect would outweigh the reduction in blood sugar seen from a concomitant reduction in dietary carbohydrate and or in those in a IR state. But the fact fat may impact insulin sensitivity/glucose metabolism is food for thought and I'd love to see more research in this area. Most studies suggest SFA exert a greater blunting of the body's ability to respond to insulin than PUFA/MUFA but this isn't conclusive. Some studies suggest it is the amount of fat rather than particular fat type.</p></blockquote><p></p>
[QUOTE="Sean_Raymond, post: 2352741, member: 403497"] This is a good point. We eat mixed meals with different macronutrients in different ratios so studies showing the effect of a particular nutrient doesn't necessarily mean this translates to what happens when we eat 'food'. A study I recently saw used fat boluses to show the effect of fat per se on insulin sensitivity reduction (in insulin sensitive subjects). Glycaemia wasn't affected in this study but that makes sense given no glucose was administered and we have non insulin dependent glucose transporters. This potential blunting of the body's response to insulin has also been shown using mixed meals with the effect increasing as the fat % of the meal is increased showing it occurred in the presence of glucose. I doubt the insulin blunting effect would outweigh the reduction in blood sugar seen from a concomitant reduction in dietary carbohydrate and or in those in a IR state. But the fact fat may impact insulin sensitivity/glucose metabolism is food for thought and I'd love to see more research in this area. Most studies suggest SFA exert a greater blunting of the body's ability to respond to insulin than PUFA/MUFA but this isn't conclusive. Some studies suggest it is the amount of fat rather than particular fat type. [/QUOTE]
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