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Fats and Insulin Resistance
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<blockquote data-quote="Sean_Raymond" data-source="post: 2354090" data-attributes="member: 403497"><p>I'll need to find a reference for you, however not everyone gets fatty deposits at injection sites (I believe it is less than 30% in T1DM and under 10% in T2DM). Different type of insulin appear to be more or less likely to cause them. My view of this centres partially around the difference in administration of insulin subcutaneously verses peripheral release of insulin. Injecting insulin at the same site has been shown to cause an immunological inflammatory response leading to accumulation of inflammatory cells/scar tissue at these sites. They are not just composed of fat. In addition, as the site becomes inflamed/develops scar tissue absorption becomes less efficient and 'possibly' some of the insulin doesn't get fully administered into the blood. Also, the insulin is injected into subcutaneous fat from where it then enters the blood. Insulin does have anabolic fat building properties but this effect is under physiological regulation when released into the circulation however injected insulin into fat tissue which then may not be fully released into the blood means perhaps the method of administration causes some fat redistribution around the surrounding tissue. No more net fat is created but the anabolic effect of insulin in the subcutaneous area causes accumulation of fat into the fat cells around the site? This last part is entirely hypothetical and not proved as far as I am aware.</p></blockquote><p></p>
[QUOTE="Sean_Raymond, post: 2354090, member: 403497"] I'll need to find a reference for you, however not everyone gets fatty deposits at injection sites (I believe it is less than 30% in T1DM and under 10% in T2DM). Different type of insulin appear to be more or less likely to cause them. My view of this centres partially around the difference in administration of insulin subcutaneously verses peripheral release of insulin. Injecting insulin at the same site has been shown to cause an immunological inflammatory response leading to accumulation of inflammatory cells/scar tissue at these sites. They are not just composed of fat. In addition, as the site becomes inflamed/develops scar tissue absorption becomes less efficient and 'possibly' some of the insulin doesn't get fully administered into the blood. Also, the insulin is injected into subcutaneous fat from where it then enters the blood. Insulin does have anabolic fat building properties but this effect is under physiological regulation when released into the circulation however injected insulin into fat tissue which then may not be fully released into the blood means perhaps the method of administration causes some fat redistribution around the surrounding tissue. No more net fat is created but the anabolic effect of insulin in the subcutaneous area causes accumulation of fat into the fat cells around the site? This last part is entirely hypothetical and not proved as far as I am aware. [/QUOTE]
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