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Fats and Insulin Resistance
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<blockquote data-quote="Sean_Raymond" data-source="post: 2354389" data-attributes="member: 403497"><p>Hi. Sorry for the late reply. I’ve missed a few posts! And thank you for sharing that experience. Insulin resistance is a very tricky, difficult to understand condition and I think it is brilliant that people here try to understand it. Many Drs struggle mightily with it as do I.</p><p></p><p>Yes, I am aware of but not over familiar with your condition. I cannot recall having worked with anyone with it although Bariatric colleagues come across it fairly often after surgery. The cause of it in those cases are understood so aren't comparable. I was just about to ask whether your condition was idiopathic or due to insulin resistance, which is linked to later reactive hypoglycaemia episodes, and you confirm it is due to insulin resistance.</p><p></p><p>From a dietary perspective, my first instinct was to look at reducing the insulin response and or rise in blood glucose so carbohydrate reduction as a approach I would consider (it wouldn't just be dietary glucose causing the spike but failure to shut down hepatic glucose production). I see you have adopted a ketogenic diet which has worked for you - once again, I am incredibly pleased to hear this and impressed that you did it outside of expert recommendations. This is such an important lesson here. I’ve used Ketogenic diets for epileptic patients only. </p><p></p><p>I’m aware we have a difference of opinion regarding insulin and weight gain/loss and I’m aware my view of this cannot explain the fact you were not eating and insulin resistant yet still gained weight. I find it incredibly frustrating on my part in failing to reconcile this experience with what I’ve seen, experienced and studied. Every time I look to the insulin hypothesis and studies into it I’m sadly also not left with the answer that you reach. Some of this may be linked to inherent genetic differences in some of us that science just hasn’t caught up with to adequately explain. But you found something that works and this is very valuable to me.</p><p></p><p>May I ask why do you think insulin resistance is caused by circulating insulin. I am still more persuaded by the idea that accumulation of fat in organs interferes with insulin signalling and insulin release (this can happen in thin people too). </p><p></p><p>Similarly, you say that calorie reduction doesn't work for people with T2DM but I have worked with and seen people with T2DM lose weight and greatly improve control of their condition. Many studies support this in both those with T2DM and without. I have trialled low carbohydrate diets and they didn't always work to lose weight and or even markedly reduce blood sugars either. In others, low carb worked well. </p><p></p><p>I am aware many have not had success with a purely calorie reducing approach however as was shown by someone who provided a study to show reducing insulin causes weight loss - the study clearly referred to calorie reduction as the cause of the weight loss. I've not seen a concrete study which, with calories controlled, insulin reduction caused weight loss.</p><p></p><p> Many here say calorie reduction didn't work for them yet eating more calories and reducing carbohydrate led to weight loss - again, based on what was said I cannot explain that or your experience. I just do not see reduced insulin levels explaining it either. </p><p></p><p>Apologies for any typos. I am furiously writing on my phone whilst at work.</p></blockquote><p></p>
[QUOTE="Sean_Raymond, post: 2354389, member: 403497"] Hi. Sorry for the late reply. I’ve missed a few posts! And thank you for sharing that experience. Insulin resistance is a very tricky, difficult to understand condition and I think it is brilliant that people here try to understand it. Many Drs struggle mightily with it as do I. Yes, I am aware of but not over familiar with your condition. I cannot recall having worked with anyone with it although Bariatric colleagues come across it fairly often after surgery. The cause of it in those cases are understood so aren't comparable. I was just about to ask whether your condition was idiopathic or due to insulin resistance, which is linked to later reactive hypoglycaemia episodes, and you confirm it is due to insulin resistance. From a dietary perspective, my first instinct was to look at reducing the insulin response and or rise in blood glucose so carbohydrate reduction as a approach I would consider (it wouldn't just be dietary glucose causing the spike but failure to shut down hepatic glucose production). I see you have adopted a ketogenic diet which has worked for you - once again, I am incredibly pleased to hear this and impressed that you did it outside of expert recommendations. This is such an important lesson here. I’ve used Ketogenic diets for epileptic patients only. I’m aware we have a difference of opinion regarding insulin and weight gain/loss and I’m aware my view of this cannot explain the fact you were not eating and insulin resistant yet still gained weight. I find it incredibly frustrating on my part in failing to reconcile this experience with what I’ve seen, experienced and studied. Every time I look to the insulin hypothesis and studies into it I’m sadly also not left with the answer that you reach. Some of this may be linked to inherent genetic differences in some of us that science just hasn’t caught up with to adequately explain. But you found something that works and this is very valuable to me. May I ask why do you think insulin resistance is caused by circulating insulin. I am still more persuaded by the idea that accumulation of fat in organs interferes with insulin signalling and insulin release (this can happen in thin people too). Similarly, you say that calorie reduction doesn't work for people with T2DM but I have worked with and seen people with T2DM lose weight and greatly improve control of their condition. Many studies support this in both those with T2DM and without. I have trialled low carbohydrate diets and they didn't always work to lose weight and or even markedly reduce blood sugars either. In others, low carb worked well. I am aware many have not had success with a purely calorie reducing approach however as was shown by someone who provided a study to show reducing insulin causes weight loss - the study clearly referred to calorie reduction as the cause of the weight loss. I've not seen a concrete study which, with calories controlled, insulin reduction caused weight loss. Many here say calorie reduction didn't work for them yet eating more calories and reducing carbohydrate led to weight loss - again, based on what was said I cannot explain that or your experience. I just do not see reduced insulin levels explaining it either. Apologies for any typos. I am furiously writing on my phone whilst at work. [/QUOTE]
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