Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Food and Nutrition
Low-carb Diet Forum
Fats and Insulin Resistance
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="Sean_Raymond" data-source="post: 2354664" data-attributes="member: 403497"><p>Thank you for sharing such details on your experiences, knowledge and views. Such posts make me realise how many gaps there are iin my knowledge and in terms of evidence as what we so far know seems to go out of the window with what has happened to you. This is quite a difficult read as I can only imagine how much difficulty this has caused you in your life, but it is also an interesting read to learn.</p><p></p><p>I was going to ask if you had used an incretins. Apologies if you have mentioned it already but can I ask if your insulin resistance and hyperinsulinaemia have been corrected.</p><p></p><p>May I also ask, and I ask to understand for my own learning and understanding of your condition. You mentioned your first phase insulin response is weak, I therefore gather that it was in the second phase where your insulin overshoots to cause the hypos. You also said you had no effective insulin to deal with the dietary glucose because of the hyperinusulinaemia - so it was only in the second phase response where over secretion of dietary induced insulin occurred did your body respond to the insulin. Do I have that correct.</p><p></p><p>The heliobacter hypothesis is deeply interesting, indeed there could be a role in many metabolic conditions related to the microbiome. I admit I must learn a lot about reactive hypoglycaemia as I haven't really gained any experience of it in my practice. I will certainly look at this hypothesis of yours and maybe knock heads together and see what we find.</p><p></p><p>Your comment that "your weird" i.e. your metabolism is just wired differently speaks more to metabolic differences between people and that we are no-where close to understanding it. There are surely many unexplored undiscovered genetic differences and anomalies between people which may affect how we respond to diet. Indeed, we know many such differences to diet exist. This in itself means we have to accept one approach isn't acceptable - a mistake many I know make. Migration and cross pollination of people over thousands of years has probably mixed genes that might have better suited to a more animal based diet and others to higher carbohydrate.</p><p></p><p>When we look at when our genome was formed the general agreement is we were in a state of feast and famine (which may explain why fasting appears to be beneficial) but we have still evolved as humans spread around the planet. One such genetic difference exerted by their specific environment is found in Inuit people who eat a largely animal/fat based diet (they do eat some plant foods such as seaweed). Yet they developed a very specific genetic adaptation to prevent them going into ketosis (as non-Inuits would) and continue using glucose as fuel. This discovery has been used to suggest this is an argument against Ketosis being an undesirable physiological state (I am not arguing that here as the protein content of their diet may have stopped them going into ketosis anyway - I am not sure how much carbohydrate they consumed either).</p><p></p><p>So. With this in mind and knowing that fat and glucose do compete for fuel useage and impact each others metabolism - possibly because historically fat and carbohydrate were rarely consumed together - and in different ratios- genes adapted for different diets got passed on all over the place which may at least partly explain more than we appreciate the differing of responses to carbohydrate. Maybe this all seems obvious. Or nonsense.</p><p></p><p>Many thanks.</p></blockquote><p></p>
[QUOTE="Sean_Raymond, post: 2354664, member: 403497"] Thank you for sharing such details on your experiences, knowledge and views. Such posts make me realise how many gaps there are iin my knowledge and in terms of evidence as what we so far know seems to go out of the window with what has happened to you. This is quite a difficult read as I can only imagine how much difficulty this has caused you in your life, but it is also an interesting read to learn. I was going to ask if you had used an incretins. Apologies if you have mentioned it already but can I ask if your insulin resistance and hyperinsulinaemia have been corrected. May I also ask, and I ask to understand for my own learning and understanding of your condition. You mentioned your first phase insulin response is weak, I therefore gather that it was in the second phase where your insulin overshoots to cause the hypos. You also said you had no effective insulin to deal with the dietary glucose because of the hyperinusulinaemia - so it was only in the second phase response where over secretion of dietary induced insulin occurred did your body respond to the insulin. Do I have that correct. The heliobacter hypothesis is deeply interesting, indeed there could be a role in many metabolic conditions related to the microbiome. I admit I must learn a lot about reactive hypoglycaemia as I haven't really gained any experience of it in my practice. I will certainly look at this hypothesis of yours and maybe knock heads together and see what we find. Your comment that "your weird" i.e. your metabolism is just wired differently speaks more to metabolic differences between people and that we are no-where close to understanding it. There are surely many unexplored undiscovered genetic differences and anomalies between people which may affect how we respond to diet. Indeed, we know many such differences to diet exist. This in itself means we have to accept one approach isn't acceptable - a mistake many I know make. Migration and cross pollination of people over thousands of years has probably mixed genes that might have better suited to a more animal based diet and others to higher carbohydrate. When we look at when our genome was formed the general agreement is we were in a state of feast and famine (which may explain why fasting appears to be beneficial) but we have still evolved as humans spread around the planet. One such genetic difference exerted by their specific environment is found in Inuit people who eat a largely animal/fat based diet (they do eat some plant foods such as seaweed). Yet they developed a very specific genetic adaptation to prevent them going into ketosis (as non-Inuits would) and continue using glucose as fuel. This discovery has been used to suggest this is an argument against Ketosis being an undesirable physiological state (I am not arguing that here as the protein content of their diet may have stopped them going into ketosis anyway - I am not sure how much carbohydrate they consumed either). So. With this in mind and knowing that fat and glucose do compete for fuel useage and impact each others metabolism - possibly because historically fat and carbohydrate were rarely consumed together - and in different ratios- genes adapted for different diets got passed on all over the place which may at least partly explain more than we appreciate the differing of responses to carbohydrate. Maybe this all seems obvious. Or nonsense. Many thanks. [/QUOTE]
Verification
Post Reply
Home
Forums
Food and Nutrition
Low-carb Diet Forum
Fats and Insulin Resistance
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…