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<blockquote data-quote="Sean_Raymond" data-source="post: 2356410" data-attributes="member: 403497"><p>Hi. </p><p></p><p>I know you posted 2 links but I believe they were to the same Study?</p><p></p><p>I'm only skimming through this and will reply when I get a chance to look at the studies. But I'd just like to respond to a few things.</p><p></p><p>First. Even if the drop in insulin led to reduction in calorie intake that would still mean that the weight was lost because of reduced intake rather than any direct effects of insulin on fat tissue Many believe insulin directly makes you fat so reducing its levels makes you lose weight - calories are not so important. This is a bit of a different hypothesis. </p><p></p><p>My main sticking point with insulin being the cause of fat gain is that the cell doesn't take direct orders from Insulin. Insulin sends a signal which the cell isn't obliged to follow - the cell will first look at ratios of specific elements to gauge energy status before deciding if it should follow Insulins request. This is because of allosteric control - essentially regulation by enzymes and biological substances (it is very technical but I can put together an explanation more detailed than the one I previously posted a few days ago). The release of Insulin is not the be all and end all of fat burning because the body hasn't evolved direct fat burning/storing pathways that simply say yes or no. Insulin is a hormone which is subject to regulation and can be overridden.</p><p></p><p>It is at this level, beyond hormonal control, that I am revisiting to see if there is someway these regulatory processes can fail because many on her clearly reduced calories and didn't lose weight but reduced carbs whilst eating more calories and still lost weight. </p><p></p><p>Regarding Insulin stimulating appetite - I had a discussion on here a while ago regarding this. My argument then was that the evidence strongly leans towards Insulin being a satiety hormone - making a person feel full - so reducing intake. I do not recall seeing any convincing evidence that indicates it promotes appetite. I'll look at those studies you posted and comment on them when I can. </p><p></p><p>Thanks</p></blockquote><p></p>
[QUOTE="Sean_Raymond, post: 2356410, member: 403497"] Hi. I know you posted 2 links but I believe they were to the same Study? I'm only skimming through this and will reply when I get a chance to look at the studies. But I'd just like to respond to a few things. First. Even if the drop in insulin led to reduction in calorie intake that would still mean that the weight was lost because of reduced intake rather than any direct effects of insulin on fat tissue Many believe insulin directly makes you fat so reducing its levels makes you lose weight - calories are not so important. This is a bit of a different hypothesis. My main sticking point with insulin being the cause of fat gain is that the cell doesn't take direct orders from Insulin. Insulin sends a signal which the cell isn't obliged to follow - the cell will first look at ratios of specific elements to gauge energy status before deciding if it should follow Insulins request. This is because of allosteric control - essentially regulation by enzymes and biological substances (it is very technical but I can put together an explanation more detailed than the one I previously posted a few days ago). The release of Insulin is not the be all and end all of fat burning because the body hasn't evolved direct fat burning/storing pathways that simply say yes or no. Insulin is a hormone which is subject to regulation and can be overridden. It is at this level, beyond hormonal control, that I am revisiting to see if there is someway these regulatory processes can fail because many on her clearly reduced calories and didn't lose weight but reduced carbs whilst eating more calories and still lost weight. Regarding Insulin stimulating appetite - I had a discussion on here a while ago regarding this. My argument then was that the evidence strongly leans towards Insulin being a satiety hormone - making a person feel full - so reducing intake. I do not recall seeing any convincing evidence that indicates it promotes appetite. I'll look at those studies you posted and comment on them when I can. Thanks [/QUOTE]
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