Why would such a person have been prescribed metformin?1. Has anyone who has no insulin resistance, not obese, low BMI, no belly fat has seen significant decrease in postprandial blood glucose with Metformin ? Means does Metformin helps in activating insulin secretion signals or affects GLP-1?
Thanks for your detailed response. There is so much in insulin signalling that is still not discovered. You could have stored insulin granules, but sometimes first phase trigger is lacking for whatever reason, hormonal/incretin etc. So what i have noticed is that insulin gets a nudge at a certain BG level and then it performs well, which makes me doubt that its more of signalling issue than production. So much is being discovered about Metformin as well so just wanted to see if anyone has personal experience of controlling postprandial in the absence of IR (anyone who understand it or keeps an eye on this). My BG could stay in 6-7 mmol for prolonged time in the absence of this insulin nudge. However, if i eat some sugar with a meal, it will take a quick spike but then will go down to 5, which makes me suspect there is some insulin signalling issue or there is a threshold.Most readers of your post will have no idea if they have insulin resistance. It is not measured by standard tests. Secondly, my understanding of what Metformin does is that it can help reduce IR in muscle tissue. Metformin does not activate insulin production. it does reduce the glucose released by the liver and I suppose this could affect the timing of the first response which is glucose step level sensitive. Remember that the first phase insulin response is the release of stored insulin from the granules in the beta cells which were charged up slowly over time prior to your meal so it is more like a dam bursting i.e. a short high spike some 10 minutes after first bite and lasting about 10 to 15 minutes only. Because it is so short, it is difficult to measure even on a CGM. Normally an oral stimulus will not trigger much of a Stage #1 response, and it is normally only visible when the stimulus is intravenous such as in the insulin clamp IVGTT test.
The booster that increases the insulin output is sulfonylurea as produced by the delta cells or by a medication such as gliclazide. Boosting GLP-1 will generally increase the time the demand signal for the insulin production is active as shown by meds such as the Glutides. These prolong the second phase insulin response.
However, if you have significant insulin resistance then boosting output is not going to gain much., i found that reducing my iR was more efficient than dosing up on meds to thrash my poor pancreas.
Maybe your body is quite happy at 6-7 and only needs to act when you force it higher by eating sugar?My BG could stay in 6-7 mmol for prolonged time in the absence of this insulin nudge. However, if i eat some sugar with a meal, it will take a quick spike but then will go down to 5,
If i know that for certain, i am more than happy to live my life, but what science says is that your optimal oxidative stress, AGEs creation is about 5.5 mmol, anything above that is definitely going to cause extra burden on your mitochondria.Maybe your body is quite happy at 6-7 and only needs to act when you force it higher by eating sugar?
I checked and i know i dont have. My HOMA-IR is 0.68. I definitely used to have before diagnosis.I'm confused. I naively thought IR was pretty well the definition of T2 diabetes, well IR leading to too high bgs? Are there T2s out there who don't have insulin resistance?
5.5mmol/l is a normal non diabetic blood sugar level, everyone diabetic or not will at some point measure above 5.5.If i know that for certain, i am more than happy to live my life, but what science says is that your optimal oxidative stress, AGEs creation is about 5.5 mmol, anything above that is definitely going to cause extra burden on your mitochondria.
1. I'm not a practitioner, so without significant proof of someone has posted it on here, I would say no! Because as others have posted.I have a question about first phase insulin response which i will breakdown into two sub questions.
1. Has anyone who has no insulin resistance, not obese, low BMI, no belly fat has seen significant decrease in postprandial blood glucose with Metformin ? Means does Metformin helps in activating insulin secretion signals or affects GLP-1?
2. Was anyone able to improve their first phase insulin increase and if so how? I saw a paper that says l glutamine increases GLP-1 and hence helps in insulin release signals.
Thanks
Is it possible that a good quality of life is possible without the perfection you seem to perpetually seek? I’d so fear you are missing out on life by continua seeking the holy grail.If i know that for certain, i am more than happy to live my life, but what science says is that your optimal oxidative stress, AGEs creation is about 5.5 mmol, anything above that is definitely going to cause extra burden on your mitochondria.
I can answer one of those: because it’s a known allergen!Trying to understand the intricacy of our bodies, there are so many questions and not enough answers.
Why is wheat written in bold letters on food products?
What are they not telling us with bleached foods?
And why don't the doctors test for insulin levels as well as hba1c levels?
Why are they using processed foods full of ingredients that are known to cause issues?
Why do GP's resort to medication before investigating the cause?
Why aren't GP's trained better in the many differences in diabetes?
And for myself, why doesn't most doctors know about my condition?
And more.
I am with you on this 100%. Been gone through this roller coaster and then enrolling into a full time nutrition degree, I just realised doctors are not helping out at least T2 as well as they should and then pharma influenced carb rich diet that regulatory bodies force onto medical system doesn't make sense either plus all other things you mentioned. I am on a journey of finding at least my personal condition to understand it better.1. I'm not a practitioner, so without significant proof of someone has posted it on here, I would say no! Because as others have posted.
Metformin does not work that way. If it did, you would not need any other meds!
2. There are drugs out there that do that!
In my experience with poor first phase insulin response. I have improved my health by not allowing my blood glucose levels to go above normal levels (ish) This does seem to reduce IR over time.
There is more to things that most endocrinologists are still trying to work out, to prove, how is the response triggered, is it by the senses to food and how much does each hormone secrete, how is it controlled?
the stomach, the gut bacteria, the intestines, the organs, the glands, the cells, and most importantly the brain itself. Even how your brain functions such as stress, anxiety, and so on, even epilepsy, Alzheimer's have seen improvement when certain foods could trigger an episode.
And then we are all individual and our environment is so different from each other!
Trying to understand the intricacy of our bodies, there are so many questions and not enough answers.
Why is wheat written in bold letters on food products?
What are they not telling us with bleached foods?
And why don't the doctors test for insulin levels as well as hba1c levels?
Why are they using processed foods full of ingredients that are known to cause issues?
Why do GP's resort to medication before investigating the cause?
Why aren't GP's trained better in the many differences in diabetes?
And for myself, why doesn't most doctors know about my condition?
And more.
That's what my goal is for now hence these questions to set up a path that works for me at least and live a more un- paranoid lifeIs it possible that a good quality of life is possible without the perfection you seem to perpetually seek? I’d so fear you are missing out on life by continua seeking the holy grail.
Its basically the response of your body (insulin) to high dose of sugar/carbs after a meal. As opposed to basal or 2nd phase which keeps working round the clock to keep your BG in normal limists.What is "first phase insulin response", how many phases are there and why are the phases relevant rather than just asking about "insulin response"?
I have not nly recently seen this "first phase insulin response" phrase mentioned and not with any explanation of what it means
I have tried Google but nonthewiser why it is asked here
I suggest you just crack on and do it, because there will always be something else to be curious or worry about.That's what my goal is for now hence these questions to set up a path that works for me at least and live a more un- paranoid life
Phase response means little to Type 1, but for a Type 2 it is akin to the bolus dose of insulin. It is helpful in reducing the peak value of a spike of glucose due to simple carbs, and the second phase follows on and is akin to the basal dose. Actually, it has been discovered that insulin release is actually cyclic with a period of about 2 minutes. The papers discussing this are quite heavy reading, but I have linked them in other threads where they were relevant.What is "first phase insulin response", how many phases are there and why are the phases relevant rather than just asking about "insulin response"?
I have not nly recently seen this "first phase insulin response" phrase mentioned and not with any explanation of what it means
I have tried Google but nonthewiser why it is asked here
In some cases, including my own, the level of carb means nothing or very little. The amount of carbs depends on your intolerance to the amount eaten. If I may. An example, to something like oats, higher than normal spike. Potatoes, very high, rice, moderate spike. And portion sizes also comes into it, on again depending on individual.Its basically the response of your body (insulin) to high dose of sugar/carbs after a meal. As opposed to basal or 2nd phase which keeps working round the clock to keep your BG in normal limists.
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