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I have been diabetic for about 15 yrs and on tablets, however a spell in hospital at the end of last year (NOT diabetes related) led me to be put on insulin - much to my dismay. During last year and always being overweight, I managed to loose 2.5 stone, in the year I have now been on insulin I have put more than that back on. After a considerable battle with my GP he has prescribed BYETTA (I have had this once before about 2 years ago so know all the problems). I am on 2x5mg per day with 2x 160mg Gliclazide and 3 Metformin. Since coming off insulin my appitite has all but gone, my question is how important is it to have substantial sized meals whilst on the Byetta and if I skip a meal do I still take the Byetta. Any help would be great.