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Gliclazide or glimepiride
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<blockquote data-quote="dbr10" data-source="post: 952283" data-attributes="member: 174581"><p>My understanding is that Metformin is the usual first line treament for diabetes, unless there is some reason you are not on it.</p><p></p><p>What is worrying is that the two drugs you mention belong to the group known as sulfonylureas.</p><p></p><p>These are the NICE recommended second line treatments. In a recent letter to the Lancet, a group of doctors criticised the guidelines and suggested that sulfonylureas were used basically because they are cheap, and not necessarily because they are best for the patient. </p><p></p><p>Sulfonylureas force the pancreas to produce more insulin. In doing so they may cause further damage and loss of function. They cause weight gain, so increasing insulin resistance, so requiring more medication. They increase the risk of heart problems. They can cause hypos.</p><p></p><p>Surely there must be safer alternatives.</p></blockquote><p></p>
[QUOTE="dbr10, post: 952283, member: 174581"] My understanding is that Metformin is the usual first line treament for diabetes, unless there is some reason you are not on it. What is worrying is that the two drugs you mention belong to the group known as sulfonylureas. These are the NICE recommended second line treatments. In a recent letter to the Lancet, a group of doctors criticised the guidelines and suggested that sulfonylureas were used basically because they are cheap, and not necessarily because they are best for the patient. Sulfonylureas force the pancreas to produce more insulin. In doing so they may cause further damage and loss of function. They cause weight gain, so increasing insulin resistance, so requiring more medication. They increase the risk of heart problems. They can cause hypos. Surely there must be safer alternatives. [/QUOTE]
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