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Diabetes Soapbox - Have Your Say
GLP-1s And Gallbladder Disease
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<blockquote data-quote="Oldvatr" data-source="post: 2621809" data-attributes="member: 196898"><p>A salutary warning, and I am sorry you have to suffer from what appears to be a medication triggered ailment. But it is not just the GLP-1 incretin mimetics. This warning should also apply to users of DPP-4 inhibitor meds, and SGLT-2 medications that also act by increasing GLP-1 activity. all these meds list pancreatitis as a rare side effect, but do not warn of gall bladder issues. But any thing that slows metbolism has the potential to cause gall bladder issues. Even diet changes such as startng a Low Carb diet, can trigger these issues, as can any diet that increases or decreases fat intake. (again LCHF has been associated wth increased risk of gallstones) i can undertand LCHF because the extra level of fat increases bile release, and this can dislodge stones that have built up over the years. I had a gallstone release earlier this year, but thankfully the increased bile was able to usher it out of the duct so the problem was solved in a short time.</p><p></p><p>I feel sorry for people now that Ozempic et al are being doled out like sweeties and wonder cures to everybody that breathes or moves. it is clear that there is a lessening of control and monitoring of the effects of these medications, so unless there is a sudden outbreak of severe issues, it will flow under the bridge of life without causing upset to the health service or the drug makers</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2621809, member: 196898"] A salutary warning, and I am sorry you have to suffer from what appears to be a medication triggered ailment. But it is not just the GLP-1 incretin mimetics. This warning should also apply to users of DPP-4 inhibitor meds, and SGLT-2 medications that also act by increasing GLP-1 activity. all these meds list pancreatitis as a rare side effect, but do not warn of gall bladder issues. But any thing that slows metbolism has the potential to cause gall bladder issues. Even diet changes such as startng a Low Carb diet, can trigger these issues, as can any diet that increases or decreases fat intake. (again LCHF has been associated wth increased risk of gallstones) i can undertand LCHF because the extra level of fat increases bile release, and this can dislodge stones that have built up over the years. I had a gallstone release earlier this year, but thankfully the increased bile was able to usher it out of the duct so the problem was solved in a short time. I feel sorry for people now that Ozempic et al are being doled out like sweeties and wonder cures to everybody that breathes or moves. it is clear that there is a lessening of control and monitoring of the effects of these medications, so unless there is a sudden outbreak of severe issues, it will flow under the bridge of life without causing upset to the health service or the drug makers [/QUOTE]
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