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Glyclozide

lotuslight

lotuslight

Well-Known Member
Messages
135
Location
Yorkshire
Type of diabetes
Type 2
Treatment type
Tablets (oral)
I just wondered if anyone has reduced carbs so much etc they were able to get off this med at done point.
I just worry il be stuck in it forever.

Also did you gain weight on it and if so how much?

Sorry for lots of questions on this.
 
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I was on maximum Gliclizide for a few years as I continued to reduce carbs and lost weight I slowly reduced it with the help of my GP until I came of it completely in 2019, I lost the majority of my weight 11st weight loss on Gliclizide so no I didn’t gain weight.

It’s was a bit of a balancing act between carbs and how much gliclizide I was on, once I started to drop into hypo territory regularly I would reduce the gliclizide and my carbs a bit more until I wasn’t in need of it anymore. I think some of those who gain weight are feeding the hypos rather than reducing the meds which is maybe why some say they gain weight.

I do have to stick to less than 20g carbs a day though, and please be aware not everyone can get off meds completely and that doesn’t mean they’ve failed, it just means their journey is different than yours and if that was the case for me I would rather be on a small dose of Gliclizide with good numbers than struggle with higher numbers without. There is no shame in needing medication to help you be well.
 
Thank you , you sound like you have very cooperative doctors.

Thank you for this information, Iv got my sugars from 115 to 100 on my own cutting carbs I’m tempted to keep trying but I had a six hour migraine yesterday and worry could be the blood sugar.

I just hate the thought of not drinking and being able to let my hair down.
 
lovinglife said:
I was on maximum Gliclizide for a few years as I continued to reduce carbs and lost weight I slowly reduced it with the help of my GP until I came of it completely in 2019, I lost the majority of my weight 11st weight loss on Gliclizide so no I didn’t gain weight.

It’s was a bit of a balancing act between carbs and how much gliclizide I was on, once I started to drop into hypo territory regularly I would reduce the gliclizide and my carbs a bit more until I wasn’t in need of it anymore. I think some of those who gain weight are feeding the hypos rather than reducing the meds which is maybe why some say they gain weight.

I do have to stick to less than 20g carbs a day though, and please be aware not everyone can get off meds completely and that doesn’t mean they’ve failed, it just means their journey is different than yours and if that was the case for me I would rather be on a small dose of Gliclizide with good numbers than struggle with higher numbers without. There is no shame in needing medication to help you be well.
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Snap! I too was maxe'd out on Glic, along with Metfomin and Actos /Avandia and my bgl rarely dropped below 20 mmol/l and usually my meter registered HI whenever I tested. I too started my journey down Low Carb lane, and also skirted hypoland as I reduced my meds. That was 8 years ago, and since then my HbA1c has remained below 48. My weight dropped from 18 stone down to 10 stone, and I took to wearing braces since my waist is now 30" whereas I had been contemplating upgrading my jeans to a 40" waist before LCHF. My weight has been consistent at 64kg since. I have chosen to maintain a minimum dose of Gliclazide (40mg/day) since it helps me to relax my low carb diet and makes it more sustainable. I am happy to use Glic as it is a med I understand and trust and it gives me no side effects. Am I thrashing my beta cells? Not really, I still follow LCHF and that one tab of glic seems to keep my mealtime levels in check nicely. for instance two nights ago I ate battered cod and my bgl only rose 0.5 mmol.l at the 2hr PP mark and had returned to baseline at 4 hrPP.

Keeping the Glic going allows my GP to prescribe test strips for my meter as per NICE NG28 for a driver needing to meet DVLA regs.
 
I was diagnosed with type 2 diabetes whilst undergoing surgery as a hospital inpatient in 2003 and prescribed 80mg gliclazide daily. I was issued with a glucometer and soon afterwards adopted a low carbohydrate, healthy fat lifestyle. As my general health improved, I was able to halve the daily dose to 40 mg, but was advised by my GP's practice nurse not to reduce it further. In 2010 metformin was added.

In December 2018, I was advised by my GP to wean myself off gliclazide. To achieve that, I reduced my carbohydrate intake from 50 grams to 20g daily. My metformin dose was increased to compensate.

I did not gain weight while taking gliclazide. That said, on coming off the drug, I lost about 12-14 lbs over the following 6 months. Friends started asking me if I was feeling okay!
 
I went from Gliclazide to Metformin because my diabetes instructor didn’t like Gliclazide. Metformin cause me bowel problems so ditched that and on Empagliflozin and low carbohydrate high fat diet. I have ups and downs because of tam LOT of stress and other Healy issues I’m trying to get sorted, but otherwise ok
 
Angela64 said:
I went from Gliclazide to Metformin because my diabetes instructor didn’t like Gliclazide. Metformin cause me bowel problems so ditched that and on Empagliflozin and low carbohydrate high fat diet. I have ups and downs because of tam LOT of stress and other Healy issues I’m trying to get sorted, but otherwise ok
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Those using a gliflozin medication while doing low carb diet need to bw aware of this advice


As one who has experienced very high ketone readings (8 mmol/l) while on an SGLT-2 medication and only doing moderate carb restriction (not keto diet) this is worrying. The gliflozins reduce '/ stop the kidneys excreting ketones which build up.

These meds are contraindicated for Low Carb eating. We have seen several incidences of DKA admissions while tking this med reported in this forum. Gliclazide does not have this effect at all.
 
Oldvatr said:
Those using a gliflozin medication while doing low carb diet need to bw aware of this advice


As one who has experienced very high ketone readings (8 mmol/l) while on an SGLT-2 medication and only doing moderate carb restriction (not keto diet) this is worrying. The gliflozins reduce '/ stop the kidneys excreting ketones which build up.

These meds are contraindicated for Low Carb eating. We have seen several incidences of DKA admissions while tking this med reported in this forum. Gliclazide does not have this effect at all.
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I do eat high proteins and carbs I doubt are low. Sadly no chance of getting a dietitian unless I pay and then who.
 
Angela64 said:
I do eat high proteins and carbs I doubt are low. Sadly no chance of getting a dietitian unless I pay and then who.
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You should contact your HCP that prescribes the medication and make them aware that you are low carbing. They should provide you with ketostix on scrip to allow you to self monitor your ketone output. It ought to be entered into the medical record that you have declared this.

Here is the NICE guidelines
cks.nice.org.uk

SGLT-2 inhibitors | Prescribing information | Diabetes - type 2 | CKS | NICE

SGLT-2 inhibitors, Prescribing information, Diabetes - type 2, CKS
cks.nice.org.uk cks.nice.org.uk
 
Saw my GP Thursday, have been given testing strips to use with my Nipro Duo, but GP wasn’t that concerned‍♀️ I’m now concerned because I ended up in A&E March and I had a reading that made them panic, called me to a bay to re-test blood and said the problem might have caused a HA, re-test appeared ok.
 
BUT, medic insisted GP must test my kidneys
 
Angela64 said:
Saw my GP Thursday, have been given testing strips to use with my Nipro Duo, but GP wasn’t that concerned‍♀️ I’m now concerned because I ended up in A&E March and I had a reading that made them panic, called me to a bay to re-test blood and said the problem might have caused a HA, re-test appeared ok.
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Could have been electoyte imbalance. High potassium can cause panic etc. My heart med does that and I got the call back after a test to go straight to A&E do not pass Go, Do not collect £200.
 
Got GP to give me Ketone strips, used one earlier and it’s ‘low’
Electrolytes - I’ve got dissolvable tablets, maybe use more often.
 
Angela64 said:
Got GP to give me Ketone strips, used one earlier and it’s ‘low’
Electrolytes - I’ve got dissolvable tablets, maybe use more often.
Click to expand...

I also have Peripheral Atrial Fibrillation and
Haemochromatosis Compound variant, this can be connected to both, iron overload.
 
I’d this when taking glyclozide do you mean pls?

(mod edit to take out now deleted quote)
 
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The quesion in the OP is in regard to Gliclazide, which does not carry a risk of DKA, What the SGLT-2 discussion above has revealed is that the SGLT-2 med induces a medical version of the ketogenic diet in a pill. I note from my other research that other meds that affect either DPP=4 or mimic GLP-1 also induce a chemical ketogenesis and similar warnings should be applied to those meds regarding Low Carb or keto diets, and also fasting.
 
lotuslight said:
I’d this when taking glyclozide do you mean pls?
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No it was a distraction from your question. Gliclazide can give hypoglycemia but that is readily treatable by eating some carbs or glucose.

Sorry to have diverted your thread, but the discussion is a safety issue that needs to be discussed but is not actually connected to your question.
 
lotuslight said:
Thank you , you sound like you have very cooperative doctors.

Thank you for this information, Iv got my sugars from 115 to 100 on my own cutting carbs I’m tempted to keep trying but I had a six hour migraine yesterday and worry could be the blood sugar.

I just hate the thought of not drinking and being able to let my hair down.
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My experience of mixing Gliclazide and alcohol, is that they do interact, and the combinatiion can drop bgl levels lower than usual. It is not a major problem since as a T2D the liver will eventually step in and raise the sugars back up naturally, but keep a sugary snack nearby or a sugary driink to reverse the drop if it becomes a problem.

If hypos become frequent, then perhaps talk to your HCP about possibly reducing the gliclazide dose temporarily. The pills split quite easily and are scored to help do that.

Glic is my friend and we've been together for several years now. Let your hair down by all means but maybe need less alcohol to get there.

(mod edit to comply with forum ethos)
 
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No! I checked and was low. I’ve no idea how often or what. She said to talk to the diabetes nurse. I really don’t know why said nurse has not said anything about ketoacidosis just just tells me I’ve got it under control by.
But if I didn’t do low carb surely I’d HAVE to inject?
I have Haemochromatosis Compiund variant, iron overload problem. Now, there is no research on this variant but it does cause health issues as the Haemochromatosis Society/association know. This variant is dismissed by many.
I also have Peripheral Atrial Fibrillation, also can be associated with GH!
I have been banging my head for months trying to get the help and support I feel I need. I’m a qualified Complimentary Therapist of 25 years. Trying to keep myself healthy and get what is needed to do that. I’ve paid literally thousands for private consultations, MRI’s scans, told I’m ok ‍♀️
But I don’t trust, because of my many experiences with hospitals have not been great.

(mod edit to take out now deleted quote. For clarity: the quote was about testing for ketones.)
 
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No! I mentioned ketoacidosis and she just said oh yes and referred to the Empagliflozin, then mentioned talking to the diabetes nurse who knows I eat low carb and who said nothing!

I am low carb, not ‘no carb’. I do not exclude all carbs.

I have been on X-Pert Diabetes course in 2021 after I was diagnosed and that trainer knew I was following low carb, said nothing about Ketoacidosis other than he didn’t like Gliclazide and like me off it. ‍♀️

(mod edit to take out now deleted quote. For clarity: the quote was about testing for ketones.)
 
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