Hba1C at 38 6 months after diagnosis

[Impy]

Hi @Irish Jenny - Just had my yearly bloods done and my Hba1c is now at 34 but my total cholesterol is now up at 5.9, Ldl is also slightly up as well. Made the mistake of eating my breakfast half an hour before I had the bloods drawn which means the results from the lipid panel are skewed from where they would have been if I hadn't.

I've got a phone conversation booked with my GP for the tail end of June (routine appointment, so nothing available before then) at which point they will recommend a statin which I will refuse.

I am aware of the studies done by Dave Feldman/Nick Norwitz re: lean mass hyper responders and also the cholesterol paradox first identified from the Framingham heart study. Basically the results from that study indicated that higher total cholesterol/ldl levels were associated with a lower all cause mortality risk than lower levels (i.e. those currently being aimed for by the current medical guidelines). Just type "cholesterol paradox" into either an internet search engine/ChatGPT for more info.

If you're interested, I've also done some research on how statins work. Apparently they inhibit the Mevalonate pathway which is where your liver produces cholesterol, the side effect of this reduces the production of Co-enzyme Q10 which is a key component of cellular energy production particularly important for organs with high energy demands like the heart, liver, and muscle. Another reason why I won't take a statin.

 

[Irish Jenny]

Hi @Irish Jenny - Just had my yearly bloods done and my Hba1c is now at 34 but my total cholesterol is now up at 5.9, Ldl is also slightly up as well. Made the mistake of eating my breakfast half an hour before I had the bloods drawn which means the results from the lipid panel are skewed from where they would have been if I hadn't.

I've got a phone conversation booked with my GP for the tail end of June (routine appointment, so nothing available before then) at which point they will recommend a statin which I will refuse.

I am aware of the studies done by Dave Feldman/Nick Norwitz re: lean mass hyper responders and also the cholesterol paradox first identified from the Framingham heart study. Basically the results from that study indicated that higher total cholesterol/ldl levels were associated with a lower all cause mortality risk than lower levels (i.e. those currently being aimed for by the current medical guidelines). Just type "cholesterol paradox" into either an internet search engine/ChatGPT for more info.

If you're interested, I've also done some research on how statins work. Apparently they inhibit the Mevalonate pathway which is where your liver produces cholesterol, the side effect of this reduces the production of Co-enzyme Q10 which is a key component of cellular energy production particularly important for organs with high energy demands like the heart, liver, and muscle. Another reason why I won't take a statin.

 

[Irish Jenny]

It's so good to meet another person who is so informed on how statins affect liver metabolism and the limitations and weaknesses of LDL testing, particularly on the NHS. How do you stay so informed? Is it continued Google/chatGPT searches or do you follow the work of certain doctors to give you the confidence to have these conversations with your GP/DN?

I'd be keen to know how that conversation goes with your GP at the end of June.

 

[Melgar]

Hi @Irish Jenny - Just had my yearly bloods done and my Hba1c is now at 34 but my total cholesterol is now up at 5.9, Ldl is also slightly up as well. Made the mistake of eating my breakfast half an hour before I had the bloods drawn which means the results from the lipid panel are skewed from where they would have been if I hadn't.

I've got a phone conversation booked with my GP for the tail end of June (routine appointment, so nothing available before then) at which point they will recommend a statin which I will refuse.

I am aware of the studies done by Dave Feldman/Nick Norwitz re: lean mass hyper responders and also the cholesterol paradox first identified from the Framingham heart study. Basically the results from that study indicated that higher total cholesterol/ldl levels were associated with a lower all cause mortality risk than lower levels (i.e. those currently being aimed for by the current medical guidelines). Just type "cholesterol paradox" into either an internet search engine/ChatGPT for more info.

If you're interested, I've also done some research on how statins work. Apparently they inhibit the Mevalonate pathway which is where your liver produces cholesterol, the side effect of this reduces the production of Co-enzyme Q10 which is a key component of cellular energy production particularly important for organs with high energy demands like the heart, liver, and muscle. Another reason why I won't take a statin.

There have been a number of discussions on LMHR phenotypes on the forum. I go back and forth on whether I am or not. I'm Lean and fit, with very low triglycerides, good HDL but high LDL cholesterol. I did the very low carb diet, during that time I didn't get my lipids done so I have no idea how high my LDLs went . Those with LMHR on very low carb diets can go ridiculously high with LDL cholesterol >8 mmol/ls with very low Triglycerides and good HDL's. I probably do fit the type. I'm on statins now, which have brought my LDLs back in range.

By the way, forum rules do not allow for AI generated material. AI draws from open source material with questionable accuracy, the end product cannot be guaranteed. Any mention of AI material contravenes forum rules.

 

[Irish Jenny]

There have been a number of discussions on LMHR phenotypes on the forum. I go back and forth on whether I am or not. I'm Lean and fit, with very low triglycerides, good HDL but high LDL cholesterol. I did the very low carb diet, during that time I didn't get my lipids done so I have no idea how high my LDLs went . Those with LMHR on very low carb diets can go ridiculously high with LDL cholesterol >8 mmol/ls with very low Triglycerides and good HDL's. I probably do fit the type. I'm on statins now, which have brought my LDLs back in range.

By the way, forum rules do not allow for AI generated material. AI draws from open source material with questionable accuracy, the end product cannot be guaranteed. Any mention of AI material contravenes forum rules.

Thanks for the advice on forum rules and sharing your story. I'll take a look at the other forum chats on LMHR with low carb.

 

[Impy]

There have been a number of discussions on LMHR phenotypes on the forum. I go back and forth on whether I am or not. I'm Lean and fit, with very low triglycerides, good HDL but high LDL cholesterol. I did the very low carb diet, during that time I didn't get my lipids done so I have no idea how high my LDLs went . Those with LMHR on very low carb diets can go ridiculously high with LDL cholesterol >8 mmol/ls with very low Triglycerides and good HDL's. I probably do fit the type. I'm on statins now, which have brought my LDLs back in range.

By the way, forum rules do not allow for AI generated material. AI draws from open source material with questionable accuracy, the end product cannot be guaranteed. Any mention of AI material contravenes forum rules.

So noted - won't do it again