One of the big problems with Diabetes is that when it comes to cognitive impairment all the Drs used to say it didn't have any effects. had to argue no end with my GP about it. She wouldn't even send me to the Endocrinologists.
I always thought it had something to do with the fact I've been on various high doses of antidepressants over the years, but now I'm thinking that perhaps it has more to do with high sugar levels.
Well it can be both, don't quote me on this but I think depression and high sugar levels are very much linked. Insulin causes the brain to release dopamine, serotonin and a few other neurotransmitters. So if your sugars are high, according to the brain there is a lack of insulin hence it isn't releasing enough serotonin which is one of the causes of depression. Antidepressants typically only make the little that is available stay active longer but they don't increase them.
Also practically speaking, if you are high you will feel awful, that in itself is darn right depressing!
Are these studies available to read anywhere online?... without having to pay for them, I mean!
Hummm, that might be tricky, I am getting access to them via the academic license so can't just copy and paste them or I would be breaching copyrights. I'll put the full references at the end of this message you could try using google scholar, worst case you get access to the Abstracts, best case some of the studies give you full text online.
I'm actually going to be running a study on prospective memory (in the form of a questionnaire) as soon as it gets through Ethics approval so will be publishing quite a bit of diabetes/neuropsychology info via twitter and the study web page. Might be some useful information in all of that if you are interested
Frankie
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References:
McCall, A.L. (1992). The impact of diabetes on the CNS. Diabetes. 41(5):557–70.
McCall, A.L. (2004). Cerebral glucose metabolism in diabetes mellitus. European Journal of Pharmacology, Feb
McCall, A.L. (2005). Altered glycemia and brain—update and potential relevance to the aging brain. Neurobiology of Aging 26S, S70–S75
Sommerfield, A.J., Deary, IJ. and Frier, B.M.(2004). Acute hyperglycemia alters mood state and impairs cognitive performance in people with type2 diabetes. Diabetes Care. 27(10):2335–40.
Malone, J.I., Hanna, S., Saporta, S., Mervis, R.F., Park, C.R., Chong, L. and Diamond, D.M. (2008). Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. Pediatric Diabetes 9(6) 531–539