Your question is a very important one and the shirt answer is YES, the body can stop absorbing humalog. I have had type one since 4byrs old so that's 48 yrs, over this time I've used all the long acting insulins. A few years ago humalog started to take a very long time for its onset, that is for it to start. Rather than begin in 20 minutes it would not begin to reduce bg for almost 2 hours on the dot. Of course before going to the endocrinologist and her telling me "what you say is impossible", I tried everything, like getting a new script and throwing out all my old humalog etc and then using, and this was the decider, some old novolog. The old novolog would begin action within 20 minutes but the brand new humalog, like the humalog I just threw away would begin action in 2 hours! So for some reason my body had developed a sort of 'tolerance' to it. I did a lot of reading at the time, most of which now I have forgotten, but there was a lot of evidence to say that over time the body can build up resistance to the specific insulin it's using. It seemed that the problems associated with it were all very personal/specific to the individual, however one thing seemed to be consistent: that after some time of the individual not using that insulin, and they would regain their tolerance. Eventually I tried using humalog again after not touching it for a few years and sure enough it worked as suspected. Sorry for my long winded reply, I just thought it would been important context, and that one could go a life time of type one and never have this but almost anyone that has experienced this will have had to been using insulin for a very long time.
