Most people are happy if they have a low Homa IR, but they never pay attention to their Homa B
I often find people with very good n optimal Homa IR (0.6, 0.9 and so on) but they have relatively high fasting blood glucose (5.5 - 6.5), how could these happen? because their fasting insulin are too low, simply put, they are NOT producing enough insulin to cover their carbs intake, So imho type 2 is not just about insulin resistant, it only happen in the early stage, as time goes by and it progresses it develops into insulin deficient too.
Example 1
Fasting glucose = 6.5 -> a bit high
Fasting insulin = 3 -> optimal
Homa IR (FG x FI)/22.5 = 0.87 -> optimal
At a glance, it looks like a very good and optimal result, but when we calculate the Homa B (20 x FI)/(FG - 3.5) = 20%, we understand why the FG is above normal value, because the pancreatic beta cells do NOT produce enough insulin to cover the carbs intake
Example 2
Fasting glucose = 4.7
Fasting insulin = 6
Homa IR = (4.7 x 6)/22.5 = 1.25
Homa IR is much higher than example 1, but when we look at the Homa B (20 x 6)/(4.7 - 3.5) = 100% we know why the fasting glucose is much lower and within the normal range, because the pancreatic beta cells produce enough insulin to cover the carbs intake, so what are your Homa IR and Homa B?
P.S.
Normal Homa IR = 0.5 - 1.4 some people say less than 1 is optimal
Normal Homa B = 70-150%
Normal insulin = 2.6 - 24.9
some people (lots of them) say the optimal insulin level is closer to minimal value (<5)
I often find people with very good n optimal Homa IR (0.6, 0.9 and so on) but they have relatively high fasting blood glucose (5.5 - 6.5), how could these happen? because their fasting insulin are too low, simply put, they are NOT producing enough insulin to cover their carbs intake, So imho type 2 is not just about insulin resistant, it only happen in the early stage, as time goes by and it progresses it develops into insulin deficient too.
Example 1
Fasting glucose = 6.5 -> a bit high
Fasting insulin = 3 -> optimal
Homa IR (FG x FI)/22.5 = 0.87 -> optimal
At a glance, it looks like a very good and optimal result, but when we calculate the Homa B (20 x FI)/(FG - 3.5) = 20%, we understand why the FG is above normal value, because the pancreatic beta cells do NOT produce enough insulin to cover the carbs intake
Example 2
Fasting glucose = 4.7
Fasting insulin = 6
Homa IR = (4.7 x 6)/22.5 = 1.25
Homa IR is much higher than example 1, but when we look at the Homa B (20 x 6)/(4.7 - 3.5) = 100% we know why the fasting glucose is much lower and within the normal range, because the pancreatic beta cells produce enough insulin to cover the carbs intake, so what are your Homa IR and Homa B?
P.S.
Normal Homa IR = 0.5 - 1.4 some people say less than 1 is optimal
Normal Homa B = 70-150%
Normal insulin = 2.6 - 24.9
some people (lots of them) say the optimal insulin level is closer to minimal value (<5)
