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How can I reduce fasting insulin levels
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<blockquote data-quote="Lotties" data-source="post: 2189899" data-attributes="member: 517727"><p>I have, in general it seems, steady but raised fasting insulin levels around 6.5mmol/L. Even when not on my prednisolone (forgot it and it has short half-life)</p><p>Obviously, I am looking for ways to reduce fasting glucose to non-diabetic levels. </p><p>I find it easier to stick to a diet regime that has a scientific basis that I can be persuaded by. </p><p>Jason Fung and many others, promote fasting and low-carb but I see no mechanisms proposed (that I understand and hence can evaluate) other than emprical and statistical studies.</p><p>This old article proposes a mechanism, indicating amyloids in the pancreas may disrupt a proposed signalling mechanism between the glucagon and insulin secreting cells in T2D.</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2342944/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2342944/</a></p><p>The article relates signalling not in biochemical terms but in control theory terms so is a bit different read than average if you aren't familiar.</p><p>It seems to indicate that amyloids are one of the problems and from what i hear is that fasting can help remove these via autophagy, at least in the brain.</p><p>Does anyone know of any, more recent or more relevant scientific papers?</p><p>Lotties' a nerd today <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink ;)" loading="lazy" data-shortname=";)" /></p></blockquote><p></p>
[QUOTE="Lotties, post: 2189899, member: 517727"] I have, in general it seems, steady but raised fasting insulin levels around 6.5mmol/L. Even when not on my prednisolone (forgot it and it has short half-life) Obviously, I am looking for ways to reduce fasting glucose to non-diabetic levels. I find it easier to stick to a diet regime that has a scientific basis that I can be persuaded by. Jason Fung and many others, promote fasting and low-carb but I see no mechanisms proposed (that I understand and hence can evaluate) other than emprical and statistical studies. This old article proposes a mechanism, indicating amyloids in the pancreas may disrupt a proposed signalling mechanism between the glucagon and insulin secreting cells in T2D. [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2342944/[/URL] The article relates signalling not in biochemical terms but in control theory terms so is a bit different read than average if you aren't familiar. It seems to indicate that amyloids are one of the problems and from what i hear is that fasting can help remove these via autophagy, at least in the brain. Does anyone know of any, more recent or more relevant scientific papers? Lotties' a nerd today ;) [/QUOTE]
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