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Type 2 I am going on Ozempic

I am on this drug as well as metformin and gliclazide. Gliclazide puts weight on and Ozempic takes it off. I started on ,25 then ,5 and now 1mg. I lost half a stone in a month but found that I am very unwell. Very clammy, trembly and light headed. My diabetic nurse has brought forward my consultant appointment from November to 2 weeks time. Everything I eat is turning to liquid and I have stopped taking gliclazide as my glucose levels are very low for me
 
Jazza6 said:
Hi, I have started Trulicity which is basically the same as Ozempic. Only been using for two weeks but haven’t suffered any side-effects as yet and hopefully that will continue. I’m on 0.75 mcg and this will go up I think to 1.25 next week or in the next couple of weeks. hoping this works out for you.
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I was on trulicity but had to come off it as I was violently sick
 
whiteorchid said:
I was on trulicity but had to come off it as I was violently sick
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Trulicity and Ozempic and Victoza all belong to the same family, They work in the same way as each other and will possibly have similar side effect risks but with minor differences.
Do you measure your own blood sugar levels? How low are you going? Could the effects you are experiencing be hypo's? The gastric ones are a common one for this family of meds but usually nausea and vomiting, but you may also be seeing gastric upset from the Metformin.

If you are losing liquid through vomiting or the other, then please make sure that you hydrate adequately to prevent dehydration.
 
Unfortunately there is a problem with the Ozempic and therefore i have now been informed i will go into trucility or however you write it.
 
UsmanMo96 said:
Unfortunately there is a problem with the Ozempic and therefore i have now been informed i will go into trucility or however you write it.
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Do you have any kidney problems? The reported difficulty with Ozempic today is that it has been linked to new or worsened kidney disease, up to and including kidney failure. It is exacerbated by dehydration following vomiting or dia-whatsit (can never spell it)

Unfortunately Trulicity is from the same family and is a similar medication, so may suffer similar problem that so far has not been associated with it. Keep hydrated.

There is also another warning on this family of meds that they can trigger pancreatitis if the vomiting and diawhatsit persist or if you get abdominal pain. they are linked to both acute pancreatitis and also the chronic permanent form of it.

This is on top of the warning about thyroid cancer that these meds carry a risk of.
https://www.healthline.com/health/drugs/ozempic-side-effects#warnings
 
Oldvatr said:
Do you have any kidney problems? The reported difficulty with Ozempic today is that it has been linked to new or worsened kidney disease, up to and including kidney failure. It is exacerbated by dehydration following vomiting or dia-whatsit (can never spell it)

Unfortunately Trulicity is from the same family and is a similar medication, so may suffer similar problem that so far has not been associated with it. Keep hydrated.

There is also another warning on this family of meds that they can trigger pancreatitis if the vomiting and diawhatsit persist or if you get abdominal pain. they are linked to both acute pancreatitis and also the chronic permanent form of it.

This is on top of the warning about thyroid cancer that these meds carry a risk of.
https://www.healthline.com/health/drugs/ozempic-side-effects#warnings
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Thank you. I will look into it. Unfortunately i have no option to just take the medication and hope for the best since i have been 4 months with bad control
 
Oldvatr said:
The first member of this family was Byetta. This drug has since been withdrawn. What I post here is information on Byetta and hopefully does not apply to the follow on members of the family
https://www.prescriptiondrugjournal.com/byetta-lawsuit/
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I know medication aren't the answer and should only use if necessary. I dont have kidney problems as of yet. I was told the medication could cause pancreatitis.. which obviously is rare but anything can happen but i have not had any success with bringing my blood glucose down. I was 26mmol in the morning and the same right now.
Gliclazide metformin and sitagliptin all taken.. also i will need to discontinue sitagliptin when i start my Trucility. I hope it is a miracle drug because i want to come down to at least 8-10mmol i feel tired
 
At least there is information to allow an informed decision, and you will have seen that hydration is extremely important with this treatment.
 
Oldvatr said:
Hope it does what you need with minimum problems. There are others here reporting that it works for them so I wish you similar good fortune.
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I have read stories of people having success with the Trucility. I am thinking to stop the medication that no longer work for me as soon as i get the Trucility. No point taking medication that doesnt work
 
BTW that #Phase 3 trials for these meds showed that after 68 weekly treatments the average weight loss was 5% from baseline. In the follow up phase, two thirds of that weight was regained soon after the drug was stopped. The placebo group only regained 1% back in the same period. So there is a rebound effect.
https://diabetes.medicinematters.co...ebounds-after-semaglutide-withdrawal/20384552

The trials for diabetics also used a Low Calorie Low fat diet at the same time. The trials were paid for and executed by the drug companies. the data from those trials are not available for independent analysis. No serious events were reported in any of the trials.#

Ozempic is now fully licenced for the treatment of obesity in adults
https://www.nice.org.uk/news/article/nice-recommends-new-drug-for-people-living-with-obesity
Note that this is a non diabetic use, so anyone can apply. In the USA heart patients are excluded, but no other exclusions apply.

So it is being prescribed to people who have no access to glucose measuring equipment,and would not recognise a hypo if they met one. Similarly they will be unaware of DKA. It is not yet available off scrip as OTC but that is coming. So once again we have powerful drugs being given out like sweets. But these are not soft fluffy bunny meds. I note that for non diabetics you have to have a BMI of 35 or over, but the limit for diabetic I have seen is 27.
 
Oldvatr said:
BTW that #Phase 3 trials for these meds showed that after 68 weekly treatments the average weight loss was 5% from baseline. In the follow up phase, two thirds of that weight was regained soon after the drug was stopped. The placebo group only regained 1% back in the same period. So there is a rebound effect.
https://diabetes.medicinematters.co...ebounds-after-semaglutide-withdrawal/20384552

The trials for diabetics also used a Low Calorie Low fat diet at the same time. The trials were paid for and executed by the drug companies. the data from those trials are not available for independent analysis. No serious events were reported in any of the trials.#

Ozempic is now fully licenced for the treatment of obesity in adults
https://www.nice.org.uk/news/article/nice-recommends-new-drug-for-people-living-with-obesity
Note that this is a non diabetic use, so anyone can apply. In the USA heart patients are excluded, but no other exclusions apply.

So it is being prescribed to people who have no access to glucose measuring equipment,and would not recognise a hypo if they met one. Similarly they will be unaware of DKA. It is not yet available off scrip as OTC but that is coming. So once again we have powerful drugs being given out like sweets. But these are not soft fluffy bunny meds. I note that for non diabetics you have to have a BMI of 35 or over, but the limit for diabetic I have seen is 27.
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I wouldn't want to lose much weight because i am only 69kg and i dont need to lose much more otherwise if i was to lose weight maybe just 2 or 3 kg no more. Me personally want to just lose body fat % - I started on metformin and now i am on 2 other lowering drugs and now i will be on anymore but i know that after Trucility there isn't much other medicine i could try.
 
I will repeat what I said in an earlier post. The gliclazide is probably not working because of Insulin Resistance. You seem to be producing insulin, but not using it effectively. Trulicity and Ozempic also work by increasing insulin output, so in terms of glycemic control it too will probably have little effect. You can amaze me by proving me wrong in this.

So I think your realistic options are to lose weight and.or fat to shift the IR (which is acting as a fatberg). There are two tried and tested methods to do this - Very Low Calorie diet, which is based on meal replacement shakes, and the other is Low Carb healthy fats (LCHF) The Very Low Calorie diet has been proven to lose weight and restore insulin sensitvity, and it is also available on prescription from the NHS in the UK. Low Carb is also approved for use by the NHS (This website has a course that is recognised as effective) but I am not sure if it is available on scrip from the GP. It does present an alternative method for you rather than go for a medication that is not suitable for you (Your BMI is too low and you don't want or need to lose weight). But the VLC diet also causes significant weight loss so again is probably not suitable for you. Have you tried a low carb. keto diet? I use a Low carb diet myself but without going keto, and I maintain my weight within 1 kg. (62 - 63 kg) There is a choice other than these meds. You need to shift lipid fat probably from your pancreas.
 
Oldvatr said:
I will repeat what I said in an earlier post. The gliclazide is probably not working because of Insulin Resistance. You seem to be producing insulin, but not using it effectively. Trulicity and Ozempic also work by increasing insulin output, so in terms of glycemic control it too will probably have little effect. You can amaze me by proving me wrong in this.

So I think your realistic options are to lose weight and.or fat to shift the IR (which is acting as a fatberg). There are two tried and tested methods to do this - Very Low Calorie diet, which is based on meal replacement shakes, and the other is Low Carb healthy fats (LCHF) The Very Low Calorie diet has been proven to lose weight and restore insulin sensitvity, and it is also available on prescription from the NHS in the UK. Low Carb is also approved for use by the NHS (This website has a course that is recognised as effective) but I am not sure if it is available on scrip from the GP. It does present an alternative method for you rather than go for a medication that is not suitable for you (Your BMI is too low and you don't want or need to lose weight). But the VLC diet also causes significant weight loss so again is probably not suitable for you. Have you tried a low carb. keto diet? I use a Low carb diet myself but without going keto, and I maintain my weight within 1 kg. (62 - 63 kg) There is a choice other than these meds. You need to shift lipid fat probably from your pancreas.
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Shifting the lipid fat is what i am trying to do. My body isnt allowing me to cope
Oldvatr said:
I will repeat what I said in an earlier post. The gliclazide is probably not working because of Insulin Resistance. You seem to be producing insulin, but not using it effectively. Trulicity and Ozempic also work by increasing insulin output, so in terms of glycemic control it too will probably have little effect. You can amaze me by proving me wrong in this.
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If my body can handle the first 4 weeks. or if i see any difference from first week on the drug. i shall let you know- Although i was on Insulin for 6 months and that didn't help with my bringing down my glucose levels. sigh. -
 
PPS The Sitagliptin you already use. This med turns off the glucagon and stops it reducing insulin at the end of the cycle. As a T2D with suspected IR, this med will be ineffective since you do not need to turn the insulin off as your body is probably awash with it anyway. It will not work with the trulicity either since that does not use the normal enzyme signalling of GLP-1 by overriding it anyway.
 
UsmanMo96 said:
Hi All.

I am going off sitagliptin and going onto Ozempic if anyone has experience of being on or are on this medicine
please do tell me your experience. - All i know is its to be taken once a week and that its good for weight-loss.
hopefully it can help with bringing my blood sugar down so feel better and get active again.

i will be starting Monday. so i will see how this medicine works, I am hoping it does work for me because Gliclizide isn't no longer helping me.

I am getting my C-peptide checked again too.
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I am on Ozempic, having previously been on Victosa. Both made me feel extremely sick and changed my eating habits dramatically in that I could go out for a meal, take one look at the menu and suddenly not want anything. Hot weather seemed to affect me too where I would suddenly feel nauseous. It's taken a long time but it has just started to settle. Sometimes I would have a break for a week and this would help. I was on gliclazide but DN says it is an old drug and not used any more. I have also been on animal insulin for a number of years, just injecting one dose per day. However, it has never really controlled my bs. Recently my DN has tried human insulin whereby I inject different doses, one about 8 am and the other at 4pm. Having been disillusioned for more years than I care to remember I was presently surprised to get readings between 5.5 and 7.9. I can't remember when it was this low ever, usually it would be between 10 and 15. I also try to keep to low carb, not always successfully, and have started only to eat between 11am and 8pm. I know this won't work for everyone but the Ozempic means I'm not hungry in the morning. On a separate note about Metformin, it really didn't suit me and I ended up with kidney failure in 2010, hence the gliclizide. The medical profession refused to believe Metformin was the cause and about a month ago my DN asked me to try it again. I was very reluctant but she said they would test my kidneys after 2 weeks. On receiving the results I was told to stop taking it immediately. Seems I can't tolerate it. Hope you find this useful.
 
chris2016 said:
I am on Ozempic, having previously been on Victosa. Both made me feel extremely sick and changed my eating habits dramatically in that I could go out for a meal, take one look at the menu and suddenly not want anything. Hot weather seemed to affect me too where I would suddenly feel nauseous. It's taken a long time but it has just started to settle. Sometimes I would have a break for a week and this would help. I was on gliclazide but DN says it is an old drug and not used any more. I have also been on animal insulin for a number of years, just injecting one dose per day. However, it has never really controlled my bs. Recently my DN has tried human insulin whereby I inject different doses, one about 8 am and the other at 4pm. Having been disillusioned for more years than I care to remember I was presently surprised to get readings between 5.5 and 7.9. I can't remember when it was this low ever, usually it would be between 10 and 15. I also try to keep to low carb, not always successfully, and have started only to eat between 11am and 8pm. I know this won't work for everyone but the Ozempic means I'm not hungry in the morning. On a separate note about Metformin, it really didn't suit me and I ended up with kidney failure in 2010, hence the gliclizide. The medical profession refused to believe Metformin was the cause and about a month ago my DN asked me to try it again. I was very reluctant but she said they would test my kidneys after 2 weeks. On receiving the results I was told to stop taking it immediately. Seems I can't tolerate it. Hope you find this useful.
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This is interesting.. my uncle who is on dialysis has stopped metformin too.- I was on Gliclizide also. am still on it. never knew it was a old drug..was put on sitagliptin maybe a year or 2 ago.. I really have heard a lot of stories about Trulicity. if it doesn't respond to me very well i shall be dropping it as well. rather not be sick and nauseas all the time while on a drug.. sorry to hear about the kidney failure.--- which drug are you taking now? only Ozempic and Gliclizade?
 
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