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I'm really confused

Awiiiiin

Well-Known Member
Messages
79
Hi guys
I'm 18 years old (female)
I got diagnosed 2 months ago but my type is not detected yet when I tell my doctor he is also confused I myself think it might be mody since all of my test for type 1 came back negative what do you guys think do you think a glucose tolerance test would help
 
How was the diagnosis made, @Awiiiiin ?
Have you been put on any medication?
 
Pipp said:
How was the diagnosis made, @Awiiiiin ?
Have you been put on any medication?
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Yes at first he putted me on Metformin/sitagliptin and diamacron weirdly I had really quick response to them but after a month my respond became slower and slower, then last week I got a fever my blood sugar was really high and then he putted me on insulin. My diagnosis story is that I had symptoms for a month and since most of my relatives are diabetic I knew they were symptoms of diabetes. I had an hba1c test which came out to be 9.7
 
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Which tests for type 1 have come back negative? Have they ordered the specialist MODY tests? Which type are your relatives?

Do you have any typical indicators of type 2 as 18 is unusually young for type 2, although possible? Eg extremely carb heavy diet, excess weight especially long term etc

As I understand it it is possible to be type 1 with antibodies being negative, conversely if they are positive then it does confirm type 1.

I’m not sure what a GTT will tell you beyond the fact you are diabetic. Sometimes the various tests (cpeptide, antibodies etc) are very clear. Other times it’s remains a bit ambiguous and clinical judgement has to be applied.

A fever will likely raise levels in either type.
 
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Well I did anti GAD AB and anti insulin AB I did c peptide as well they where all negative and then I did a insulin and proinsulin test the weird things was that my insulin was slightly low but my proinsulin was high. And for the mody test they don't do it here in my country and in my relatives there is both type 1 and 2 . And yes I had excessive weight . After the insulin test my doctor said it's somewhere in between type 1 and 2. I don't even know if that exists.
 
Awiiiiin said:
After the insulin test my doctor said it's somewhere in between type 1 and 2. I don't even know if that exists.
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LADA is often called T1.5
Latent Autoimmune Diabetes in Adults

But honestly I'd have thought you were a bit young for that and I would expect you to have antibodies.

My understanding is that you need the genetic test to confirm MODY but I guess it doesn't matter what type you are if the treatment keeps your bgs under control. (Though if you have a T1 variant you will eventually need insulin so it would be extremely helpful to have a correct diagnosis). I think there are a few folk here who don't have a definite diagnosis. There are certainly many who take years to get a correct diagnosis.
 
If you do have MODY, a lot of us (but not all) respond well to low doses of sulfonylureas.
 
Awiiiiin said:
But how low exactly?!
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It's hard for me to say how low. There are 14 different types of MODY (there could be more). Some types are way more common than others. I think I recall reading that most of the more common types respond well to sulfonylureas. I think I read somewhere that some MODY's need to cut minimum dose pills into 4 pieces. Sulfonylureas can cause hypoglycemia, so it's important to get the dose right.

Mody is monogenic diabetes. This means diabetes is caused by a single mutated gene. I think this means for most/all mody people they can make insulin just fine, but it is not released into the body properly. My daughter has inherited my same gene mutation but has the opposite problem, hyperinsulinism.
 
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What I meant to add is that you can't put it in remission like you can with T2. I am able to control mody by going very low carb (<20g) but my fasting bg is still quite high, so in the future I might need insulin etc.

If sulfonylureas work well then you are likely to manage bg easily, hopefully. Assuming that you do have MODY, which is unclear.
 
https://link.springer.com/article/10.1007/s13300-020-00864-4

"In a randomized crossover study conducted nearly 20 years ago, Pearson et al. [41] showed that patients with HNF1A-MODY have about a fivefold greater response to gliclazide (80 mg twice daily) than to metformin (1 g twice daily) and about a fourfold greater response to gliclazide than patients with type 2 diabetes"

From wikipedia: "Mutations of the HNF1α gene (a homeobox gene). 30%–70% of cases. Most common type of MODY in populations with European ancestry.[10] Tend to be responsive to sulfonylureas".
 
I actually told my doc about it and he told me I was on them the (diamacron) I wrote in the second reply contain Sulfonylureas and yes I had really quick response to them which was weird and then suddenly after a month I was slowly losing my response to them and now I'm on insulin and it works just as fine .
 
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