Remember, when injecting Bydureon, you are injecting a suspension, not a liquid. That's why you get little nodules under the skin where you inject. These gradually disappear in time and never caused me any irritation. One word of warning - don't massage the nodules in the hope it will make them disappear. If you do this, you are actually releasing the medication at a faster rate than it should be released - resulted in severe nausea for me and there is a risk of hypos as well. Leave the nodules alone, they will disappear of their own accord. Bydureon was great for bringing my BG levels down, but the effect didn't kick in for 6-8 weeks - so be patient.