Insulin and cancer

CherryAA · Jul 2, 2017

http://onlinelibrary.wiley.com/doi/10.1002/ijc.30729/full

A afscinatin study of the impact of high levels of insulin ( over 10) on cancer rates . The bottom line appears to be that even if you are not overweight, higher level fasting insulin increases cancer risk, and this remains true if you are neither obese or diabetic with a stronger association in men than women

its intriguing that fasting insulin is rarely even tested !

tim2000s · Jul 2, 2017

There's long been an increased risk of cancer in T1 (as an unwanted complication) probably due to insulin being a growth hormone and T1D being associated with a lot of it.

kokhongw · Jul 3, 2017

@CherryAA You may also find this paper interesting...
The Links Between Insulin Resistance, Diabetes, and Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595327/

Caloric restriction
If the insulin resistant state can increase cancer, then it stands to reason that treatments that enhance insulin sensitivity could improve cancer. Caloric restriction has been shown to improve cancer survival, and it is thought that this could be in part through decrease in insulin and IGF1 concentrations [118]. Fine et al showed that low carb diet/ketosis induced disease stabilization or partial remission in some patients. However, disease progression was measured with PET scanning, which depends on glucose uptake and therefore might be confounded by a low carb diet and decreased insulin levels

Art Of Flowers · Jul 3, 2017

kokhongw said:
@CherryAA You may also find this paper interesting...
The Links Between Insulin Resistance, Diabetes, and Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595327/

Fasting does appear to increase life expectancy and reduce markers such as IGF1 in the body, which is associated with increased risk of cancer and other diseases. The Michael Moseley documentary Eat, Fast and Live Longer is worth watching.

Ktmpedro220 · Jul 3, 2017

Well. Can't believe it. Was diagnosed with stage 3 colon cancer last week. I'm type 1 for 32 years. Been quite healthy. Saw this post and think it's a coincidence rather than the insulin. Gutted isn't the word.

DCUKMod · Jul 3, 2017

Ktmpedro220 said:
Well. Can't believe it. Was diagnosed with stage 3 colon cancer last week. I'm type 1 for 32 years. Been quite healthy. Saw this post and think it's a coincidence rather than the insulin. Gutted isn't the word.

Hi Ktmpedro220 - I'm not going to comment on the thread topic, but just to wish you well on your unwelcome journey through your cancer treatment.

Sorry to be off-topic, @CherryAA .

donnellysdogs · Jul 3, 2017

Me too, but breast cancer.. T1-30+ years. I always been skinny / lean though and that impacted badly on my treatment and recovery.

Cancer? Think its more than insulin/diabetes etc.
Increase too prevalent despite other factors line smoking etc reducing.

Who knows? One thing for sure.. the remaining time I have (and who knows what that will be??) is having me boosting myself with turmeric and ground pepper and natural, organic stuff..like food etc....

Wishing you well@Ktmpedro220.

Tough journey. Make most of therapy centres if you have one near you. Tgey are superb. Our Robert Horrell Therapy Centre has been a life saver for me. They see you through the slicing, dicing, freezing and frying stages. Can help with rekaxation, courses, finances etc. Good Maggies centres around.

Still think something alters genes.. everyone of my step sisters/brothers (5) have cancer and now the first of their children diagnosed with a brain tumour too. None of them diabetic and no other illnesses.

Thinking of all T1's and cancer...

donnellysdogs · Jul 3, 2017

Ha, most of my blooming life has been fasting! 80% of adult life (15 to 54) only ate one meal per day)... still got cancer..

Its a lot more than links to T1... or diabetes or fadting etc

Ktmpedro220 · Jul 3, 2017

Cheers all.

kokhongw · Jul 4, 2017

Here is another paper.

Does cancer risk increase with HbA1c, independent of diabetes?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007234/

Background:
The risks for several cancer types are increased in people with diabetes. Hyperglycaemia, hyperinsulinaemia, inflammation and altered hormonal concentrations are common characteristics between the two diseases and can all be linked to hyperglycaemia.

Methods:
Here, we use glycated haemoglobin (HbA1c) as a biomarker for chronic hyperglycaemia. We explore whether cancer risk increases with HbA1c, independent of diabetes, and, therefore, if risk is already increased below the diabetic HbA1c range, by analysing data from current studies linking HbA1c to risk of several cancer types.

Results:
The data reveal that chronic hyperglycaemia correlates with increased cancer risk for a number of cancers, except prostate cancer. Evidence is also provided that risk is already increased in the pre-diabetic and normal ranges for several cancers.

Conclusions:
These results merit urgent investigation into the risks and advantages of updating recommendations for stricter glycaemic control in diabetic and non-diabetic subjects, as this could help reduce the risk of cancer incidence and mortality.

kokhongw · Jul 4, 2017

As with the recent passing of David Mendosa, inspite of our best effforts, even being a long time low carber did not prevent his cancer.

We can only try to reduce our risks...and perhaps improve our odds.

CherryAA · Jul 6, 2017

Ktmpedro220 said:
Well. Can't believe it. Was diagnosed with stage 3 colon cancer last week. I'm type 1 for 32 years. Been quite healthy. Saw this post and think it's a coincidence rather than the insulin. Gutted isn't the word.

Hi @Ktmpedro220 . I'm so sorry to hear your news. Sometimes its seems like the challenges never end. Whether coincidence or not, we all just have to deal with the cards we are dealt and sometimes those do seem to be distributed very unfairly. I wish you all the best in beating this diagnosis.

Odin004 · Jul 7, 2017

@Ktmpedro220 - I just wanted to add my voice to the above comments - I wish you well on this journey - and may you have the strength and courage to beat this.

Ktmpedro220 · Jul 7, 2017

Cheers again all.

Insulin and cancer

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