Hi, I was put on a starting dose of 100mcg based on how poor my results where, I found after about 6 weeks my heart rate when the thyroxine was absorbed went up to 139bmp as seen by a doctor and he decided to drop it down to 75mcgs. The blood test I had on my 6week check up suggested 100mcg was not enough but my heart couldn't handle it. I'm currently on 120 basal units and a ratio of 1:1 bolus with extras for the spikes I have, the basal has risen since dropping from 100mcgs which makes sense after what you have just said. Did they treat your insulin resistance or did you just use high doses until your thyroid leveled out? I haven't been told any information related to diabetes and thyroid problems I'm finding it like a full time job trying to research my own diseases