Hi
I've been T2 for 5 years, started with Metformin SR max dose then Gliclazide was added and increased to max dose. Each of these steps had an effect but only in the region of, say, 1% HBA1C reduction and dosage increase has a non-linear effect i.e. the effect is not double for double dose. There are some useful papers on the NHS website which show the typical HBA1C effects for these drugs and dosages. Note these are typical and everyone is different! Like the other contributor, I have lost weight with Gliclazide which proves that you can only generalise with regard to diabetes. I am maybe near to having insulin if my recent HBA1C test proves as I expect, but I would certainly go through Gliclazide again to help control my BS and it has caused me no side effects. My weight loss is probably recent low carbing, learned from this website, together with visits to the gym which I've done for years.