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<blockquote data-quote="Brunneria" data-source="post: 2019719" data-attributes="member: 41816"><p>[USER=468347]@mazza 2[/USER] </p><p>I think, as with most things, there are shades of grey here.</p><p></p><p>Beta cell death definitely happens - to some people. </p><p>And it is more likely to happen the longer your beta cells are smothered in fat, or over worked by having to produce massive amounts of insulin to overcome insulin resistance.</p><p>Likewise, not everyone has a fatty liver in the first place, so those individuals’ beta cells don’t need defatting.</p><p></p><p>There are several different forms of Glucose dysregulation all grouped together under the same type 2 name (including misdiagnosis) and i have always thought that Jason Fung is too simplistic claiming that fasting and weight loss is a catch all solution. Likewise, I have always thought that the Newcastle Diet’s focus on defatting the liver through weight loss is also too simplistic - as shown by their 40% reversal success rate.</p><p></p><p>Having said that, these treatments are highly effective for many. So just because it doesn’t work for everyone, doesn’t mean that they are not very useful treatment options - after appropriate assessment to identify those patients who will benefit.</p><p></p><p>As you have pointed out, losing weight and defatting the liver, and reducing insulin resistance are great things to achieve, but glucose dysregulation doesn’t <em><strong>always </strong></em>just disappear with fasting and weight loss. They probably reduce significantly. But for some of us, the the insulin resistance came first, and the weight gain (subcutaneous or liver) came later. In which case, losing the weight isn’t necessarily going to address the root cause, which may be environmental, genetic, age related, medication induced, or due to other health conditions.</p></blockquote><p></p>
[QUOTE="Brunneria, post: 2019719, member: 41816"] [USER=468347]@mazza 2[/USER] I think, as with most things, there are shades of grey here. Beta cell death definitely happens - to some people. And it is more likely to happen the longer your beta cells are smothered in fat, or over worked by having to produce massive amounts of insulin to overcome insulin resistance. Likewise, not everyone has a fatty liver in the first place, so those individuals’ beta cells don’t need defatting. There are several different forms of Glucose dysregulation all grouped together under the same type 2 name (including misdiagnosis) and i have always thought that Jason Fung is too simplistic claiming that fasting and weight loss is a catch all solution. Likewise, I have always thought that the Newcastle Diet’s focus on defatting the liver through weight loss is also too simplistic - as shown by their 40% reversal success rate. Having said that, these treatments are highly effective for many. So just because it doesn’t work for everyone, doesn’t mean that they are not very useful treatment options - after appropriate assessment to identify those patients who will benefit. As you have pointed out, losing weight and defatting the liver, and reducing insulin resistance are great things to achieve, but glucose dysregulation doesn’t [I][B]always [/B][/I]just disappear with fasting and weight loss. They probably reduce significantly. But for some of us, the the insulin resistance came first, and the weight gain (subcutaneous or liver) came later. In which case, losing the weight isn’t necessarily going to address the root cause, which may be environmental, genetic, age related, medication induced, or due to other health conditions. [/QUOTE]
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