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<blockquote data-quote="Oldvatr" data-source="post: 2020826" data-attributes="member: 196898"><p>There are two phases of insulin response that we normally get in response to eating carbohydrates. Stage 1 insulin is triggered as soon as sweet carbs hit the tongue by releasing the enzyme amylase, and then Stage 2 starts when carbs start being digested in the duodenum and the small intestine. The first stage is fast acting and is to soften the initial sugar spike, then the second stage lasts while carbs are being absorbed into the bloodstream. The body normally handles turning these insulin taps on and off automatically, but in T2D it seems we either lose the ability for stage 1, or we do not switch off Stage 2 at the correct time. Some artificial sweetners are bad for T2D in that they also trigger amylase stage 1 even though there may not be any significant carbs to follow, and this does not help hyperinsulinemia.</p><p></p><p>So as Insulin Resistance reduces following an appropriate diet, then we may see an improvement in post prandial readings as the insulin response improves, and this may give some surprising drops after a meal, especially if the Stage 1 response improves. Stage 1 is normally associated with the insulin to muscle pathway, and this often responds first with the glycogen stores being depleted by the diet leading to weight loss with the associated water loss. This may explain why the 2 hr PP can drop so suddenly, but the 4 hr PP may not drop so much. For example the Newcastle diet which is calorie restricted diet, noted that there was an early improvement in blood sugars directly correponding to weight loss, which was actually the glycogen stores depleting. It took longer to start depleting the liver stores and the adipose fat needed to achieve remission.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 2020826, member: 196898"] There are two phases of insulin response that we normally get in response to eating carbohydrates. Stage 1 insulin is triggered as soon as sweet carbs hit the tongue by releasing the enzyme amylase, and then Stage 2 starts when carbs start being digested in the duodenum and the small intestine. The first stage is fast acting and is to soften the initial sugar spike, then the second stage lasts while carbs are being absorbed into the bloodstream. The body normally handles turning these insulin taps on and off automatically, but in T2D it seems we either lose the ability for stage 1, or we do not switch off Stage 2 at the correct time. Some artificial sweetners are bad for T2D in that they also trigger amylase stage 1 even though there may not be any significant carbs to follow, and this does not help hyperinsulinemia. So as Insulin Resistance reduces following an appropriate diet, then we may see an improvement in post prandial readings as the insulin response improves, and this may give some surprising drops after a meal, especially if the Stage 1 response improves. Stage 1 is normally associated with the insulin to muscle pathway, and this often responds first with the glycogen stores being depleted by the diet leading to weight loss with the associated water loss. This may explain why the 2 hr PP can drop so suddenly, but the 4 hr PP may not drop so much. For example the Newcastle diet which is calorie restricted diet, noted that there was an early improvement in blood sugars directly correponding to weight loss, which was actually the glycogen stores depleting. It took longer to start depleting the liver stores and the adipose fat needed to achieve remission. [/QUOTE]
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