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Message: <blockquote data-quote="AloeSvea" data-source="post: 1597451" data-attributes="member: 150927">After reading this thread, I went online to look for the info on 'physiological insulin resistance' (which apparently increases the DP in keto eaters, all of them - not just diabetics), but I got waylaid in Dr Fung's blog entries (very enjoyable but not useful for this thread. Many apologies!). I don't really understand it myself, but there is some body mechanism when in fat-burning mode. There are a heap of scientific papers and research on mice on this, but I won't include it (but you can find them easily online if you plug in physiological insulin resistance in the search.But if I want an easy to understand explanation I often go to Mark Sisson in his 'Mark's Daily Apple' blog. Here is his explanation:"...going very low carb – to around or below 10% of calories, or full-blown ketogenic – can induce “physiological” insulin resistance. Physiological insulin resistance is an adaptation, a normal biological reaction to a lack of dietary glucose. As I’ve said in the past, the <a href="https://www.marksdailyapple.com/how-much-glucose-does-your-brain-really-need/" target="_blank">brain must have glucose</a>. It can use <a href="https://www.marksdailyapple.com/dear-mark-ketosis/" target="_blank">ketones</a> and lactate quite effectively, thus reducing the glucose requirement, but at the end of the day it still requires a portion of glucose. Now, in a low-glucose state, where the body senses that dietary glucose might not be coming anytime soon, peripheral insulin resistance is triggered. This prevents the muscles from taking up “precious” glucose that the brain requires. The brain’s sensitivity to <a href="https://www.marksdailyapple.com/dairy-insulin/#axzz23xKt6BQa" target="_blank">insulin</a> is preserved, allowing it to grab what glucose it needs from the paltry – but sufficient – levels available to it.It appears that weight loss is the deciding factor, and since low carb diets tend to be more effective at inducing weight loss in subjects, they also tend to be better at reducing insulin resistance in insulin-resistant, overweight people. Once you’re lean and weight stable, though, very low carb diets (less than 10% of calories from carbs) can reduce insulin sensitivity. This is normal and totally necessary in the context of a very low carb diet. If we didn’t become insulin resistant while eating very low carb, our brain wouldn’t be able to get the glucose it needed to keep us alive."Dr Fung says not to worry about it. I find it hard not to worry about higher FBGs too. As diabetics how can we not? So I don't have an answer to this one.</blockquote>

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