A
borofergie said:Ketones can be a sign of ketoacidosis, which is very, very bad.
They can also be a sign of ketosis, which is very, very, good for weight loss, and not at all harmful.
noblehead said:My Endo has always insisted both are harmful.
Has your Endo much experience of ketosis in his patients?noblehead said:My Endo has always insisted both are harmful.
However, during very low carbohydrate intake, the regulated and controlled production of ketone bodies causes a harmless physiological state known as dietary ketosis. In ketosis, the blood pH remains buffered within normal limits [5]. Ketone bodies have effects on insulin and glucagon secretions that potentially contribute to the control of the rate of their own formation because of antilipolytic and lipolytic hormones, respectively [9]. Ketones also have a direct inhibitory effect on lipolysis in adipose tissue [10].
Interestingly, the effects of ketone body metabolism suggest that mild ketosis may offer therapeutic potential in a variety of different common and rare disease states [11]. The large categories of disease for which ketones may have therapeutic effects are: 1) diseases of substrate insufficiency or insulin resistance; 2) diseases resulting from free radical damage; and 3) disease resulting from hypoxia [11].
..And then make him eat pork scratchings dipped in Cornish clotted cream.borofergie said:I'll hold him Swim, you hit him.
Paul1976 said:..And then make him eat pork scratchings dipped in Cornish clotted cream.borofergie said:I'll hold him Swim, you hit him.
borofergie said:That sounds like an excellent last meal for me tonight, before I go "Whole 30" tomorrow.
phoenix said:I should think that in a hospital setting, a doctor has a lot of experience of high levels of ketosis, which in the worst case scenario ends up in a coma in ICU. Perhaps it's understandable that h/shes very wary.
Where did you read that? Levels of 15-25mml/l are very high.Dietary ketosis produces plasma ketone levels of 0.5 - 5 mmol/l
Ketoacidosis kicks in between 15-25 mmol/
This 10-fold range of serum ketones, from 0.5 to 5mmol/l is your body's normal physiolocial response to varying degrees of dietary carbohydrate and protein restriction. This response range is called 'nutriotional ketosis' and is associated with metabolic adaptions allowing your body to maintain a stable set of inter-organ fuel homeostasis. This process is dependent of an adequate, albeit minimal, ability of the pancreas to produce insulin in resonse to dietary proteins and serum ketones, thus maintaining serum B-OHB in the range where it replaces much of your body't (and you brain's) need for glucose without distroting the whole-body acid-base balance.
Nutritional ketosis is by definition a begnign metabolic state that gives human metabolism the flexibility to deal with famine or major shifts in available dietary fuels. By contrast "diabetic ketoacidosis" is an unstable and dangerous condition that occurs when there in inadequate pancreatic insulin respnse to regulate serum B-OHB. This occurs only in T1 diabetics or in late stage T2 diabetes with advanced pancreatic burnout. In this setting of deficient insulin, when exigenous insulin is withheld, serum B-OHB levels reach the 15-25 mmol/l range, 5 to 10 times higher than the levels characteristic of nutrionional ketosis".
noblehead said:http://women.webmd.com/guide/high-protein-low-carbohydrate-diets
What Are the Risks Linked to High Protein, Low-Carb Diets?
High protein, low-carb diets can cause a number of health problems, including:
I wonder if the above explanation of the risks associated with ketogenic diets is why diabetes consultants are concerned when their patients are in ketosis or following a ketogenic diet?
noblehead said:I wonder if the above explanation of the risks associated with ketogenic diets is why diabetes consultants are concerned when their patients are in ketosis or following a ketogenic diet?
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