Lantus

Hi Fujifilm,
I'm afraid i haven't all the answers your looking for, but i can suggest Levemir as an alternative to Lantus. My son changed to Levemir after a nightmare experience on Lantus, and for him the change has been good. You'll find quite a few members on the site who have also dumped the Lantus in favour of Levemir, hopefully they'l be along shortly, to give advise and encouragement.
Best of luck,
Suzi x

 

I would echo the suggestion to try Levemir. Although I didn't have any side-effects with Lantus I have far better control with Levemir. You may need to take Levemir twice a day depending on your dose though, as smaller doses of Levemir don't act for as long as larger ones.

Re your non-regular routine, DAFNE or something similar would cope with this easily. That means you don't have to eat at specific times or specific amounts of carbohydrate, you learn to adjust your insulin to suit your lifestyle, rather than the other way round. You just need to make sure you take your Lantus or Levemir at the same time each day, then inject Humalog or similar if/when you eat. No more having to eat when you don't feel hungry. Not all hospitals offer DAFNE but there are other similar programmes with other names, and an online version.

 

Hi Fujifilm
That's a long time to have been on Lantus, didn't think it had been around that long. After 10 years I'd say you've got off lightly compared to other patients unfortunate to have been prescribed this garbage.
Clinical trials of Lantus (Glargine) on type-1s were only done over a period of 28 weeks prior to licensing, and many people suffer horrific side effects after being on it for over a year. I suffered side-effects within months, and for the following 4 years, before discovering the relationship between my deteriorating health, fluctuating unpredictable BG control and Lantus.
More and more people are coming out of the woodwork, and with any luck doctors and other health professionals will wake up to the problems associated with Lantus.
Please don't forget to report any adverse reactions, poor BG included, to the MHRA Yellow Card Scheme at yellowcard.mhra.gov.uk

Jus

 

Hi Fujifilm,

Sorry to hear you are experiencing problems with the GM synthetic analogue Lantus. You are certainly not alone and unfortunately there appears to be an increasing number of diabetics using Lantus that are experiencing significant problems with it.

I would like to stress that as diabetics “we have a voice to make a choice” for trying insulin’s which help us achieve good glycaemic control and provide a good quality of life.

Unfortunately what can sometimes happen is that diabetes care both Type 1 & 2 in the UK is protocol driven and thus diabetics are funneled down a one size fits all approach with regard to many aspects of their management including type of insulin.

Whatever you choose to try it’s about maximising the benefit for you and as no two diabetics are the same everyone’s experience of using the long acting basal insulin’s will vary. As a very general rule of thumb it is recommended that you should try a new regime for 6 months and evaluate as you go along and if whatever insulin you opt for does not work for you then try another one. I feel that often diabetics are encouraged to stay on unsuitable insulin far too long rather than being given the option of trying another type of insulin.

Long/intermediate acting insulin’s available in UK – September 2009

Animal Insulin
Hypurin Porcine Isophane
Hypurin Bovine Isophane

Human Synthetic Insulin
Insulatard
Humulin I
Insuman Basal

GM Synthetic Analogue
Levemir
Lantus

I would encourage you to report the side effects you are experiencing on Lantus to the MHRA - this can be completed very easily online at http://www.yellowcard.gov.uk.

I would also suggest you contact the IDDT – Insulin Dependent Diabetes Trust http://www.iddtinternational.org as they are very supportive and informative on the Lantus difficulties/changing insulin’s.

Hope you get things sorted.

Best wishes

Txx

 

Hi Fuji

I know much is written on the web about using bolus/basal and being able to eat exactly when you feel like it, but in reality relying on basal insulin such as Lantus or Levemir to keep you stabilized for hours on end without eating is asking for problems. Lantus for sure does not really give a full 24hr coverage so that is why people who only want to inject it once a day find that they have to compensate for its lack of control by injecting larger bolus doses. I would take a guess that you only get about 15hrs cover from it hence the reason why you have to use 10units of Humalog for breakfast to cover a banana? Levemir is a bit better to use as its action is more gentle in its bg lowering effect but for best effect, needs to be injected twice a day. Whether you get on all ok by switching to Levemir or indeed by changing to another insulin as Kewgirl mentions, will again rest on you keeping your control together by eating more regularly. If because of your job, you are unable to do that, then think about pushing for an insulin pump. You will then only have to deal with one insulin to be your bolus and basal.

You ask about switching from Humalog. When I first started to use MDI, I used Humalog with Lantus but asked to switch from Humalog because of hypos and feeling tired early evening (falling asleep for approx 2hrs every night). I stayed with Lantus but switched to Apidra and was much better hypo wise and less tired. Apidra's action is meant to be 'in and out' although its action on bg can last nearly as long as Humalog but is worth considering.

Good luck on what you decide to do

 

HI Fujifilm, from my experience of a few long-acting insulins, I have to say Hypurin Porcine is far superior to any I've been on in 20 years. I was on a few different long-acting synthetic 'human' insulins and then the dreaded Lantus :evil: I've never tried Levemir, nor would I- its' as poorly tested as Lantus, and could potentially be just as damaging to people's health.
What people must realise is that Lantus, Levemir, Apidra, Humalog, Novorapid,(have I missed any?), are not insulin at all. The reason why people report more stable control and better health on purified animal insulin, is because it IS insulin.
We have no choice as type-1s to take medication,and all insulins (and non!) contain preservatives. Aside from preservatives what exactly is in analogue insulin?
I look forward to the demise of Lantus, and I hope it's soon.
i'm quite sure you'll feel better as soon as you get of Lantus, as I and many other people report. Keep us posted on how you get on.
Best of luck
Jus

 

Looking up the safety profile of Novo insulin, this is worth reading:
http://www.novonordisk.co.uk/documents/ ... ofiles.asp

 

I stick by what I said. The safety and long-term implications of analogue insulins including Levemir is unknown. I became so chronically ill on Lantus in a relatively short period of time, so have many other people. There is a problem with it, and I don't mean the recent implied cancer link.
If Novo Nordisk and Sanofi Aventis are so confident of the safety of their insulins, why does Sanofi Aventis state on their website that Lantus should only be prescribed in pregnancy where necessary.
As for Levemir, I found this info:
http://emc.medicines.org.uk/document.as ... #PREGNANCY

Patients taking these insulins are unwitting participants in long-term safety studies. However results of these should not be based only on HBa1c results. When I was ill on Lantus, I continually reported my ailments and fluctuating control to my hospital Diabetic Clinic. I have recently discovered that they were not recorded in my notes. Also as my HBa1c was within the 'normal range' during this time,my notes stated that I had "good glycaemic control", despite my reporting to the consultant that I was having daily fluctuations between 2 -15! I have since made a formal complaint to the hospital involved, and my notes have been amended.

Fujifilm, I forgot to say regarding Hypurin Porcine Isophane, that many people split the dose to ensure a 24 hour action. I take 22 units am and 12 units pm.
Jus

 

Hi Fujifilm
Be wary when asking bout the DAFNE course. It's been said on this forum that only patients on Analogue Insulins are offered places :evil: It may give your doctor an excuse for not changing your medication.
Been on the phone to yet another aggrieved Lantus 'ginuea pig' this afternoon, also due to see doc this week. You are not alone! It is becoming increasingly evident that feeling 'kak' and being on Lantus go hand in hand.
Jus