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<blockquote data-quote="kokhongw" data-source="post: 1866874" data-attributes="member: 277199"><p>The conclusion from the actual referenced study...</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/</a></p><p>"<strong><span style="font-size: 18px">Conclusion</span></strong></p><p>Low-carbohydrate diets were associated with a significantly higher risk of all-cause mortality and th<strong>ey were not significantly associated with a risk of CVD mortality and incidence</strong>. However, this analysis is based on limited observational studies and large-scale trials on the complex interactions between low-carbohydrate diets and long-term outcomes are needed."</p><p></p><p>My cursory layman understanding is that those on Keto/low-carb diet are likely to die from something else...NOT CVD...</p><p></p><p>Then again...these are the limitations of such studies...</p><p>"The adjustment factors and the risk of bias among the studies are summarized in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/table/pone-0055030-t002/" target="_blank"><strong>Table 2</strong></a> and <strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030.s001" target="_blank">Table S1</a></strong>, respectively. <strong>Major confounding factors such as total energy intake were not stated in two studies. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-GarciaPalmieri1" target="_blank">[23]</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-Massimino1" target="_blank">[32]</a> Few inspected any updates of the carbohydrate intake over the follow-up period. </strong>Protein source was added to analysis in 3 studies. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-Fung1" target="_blank">[7]</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-Lagiou1" target="_blank">[9]</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-Halton1" target="_blank">[30]</a> The risk of bias among the researches involved in the meta-analysis was low."</p><p></p><p>So we are free to interpret it in any way and wonder if it is really low carb... Frankly no one has any concrete data for long term effects of keto/low carb diet 5,10,15,20 years ...those who argue against it simply don't have the hard data at the moment because no researchers would be funded by pharma for such "dangerous" studies...</p></blockquote><p></p>
[QUOTE="kokhongw, post: 1866874, member: 277199"] The conclusion from the actual referenced study... [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/[/URL] "[B][SIZE=5]Conclusion[/SIZE][/B] Low-carbohydrate diets were associated with a significantly higher risk of all-cause mortality and th[B]ey were not significantly associated with a risk of CVD mortality and incidence[/B]. However, this analysis is based on limited observational studies and large-scale trials on the complex interactions between low-carbohydrate diets and long-term outcomes are needed." My cursory layman understanding is that those on Keto/low-carb diet are likely to die from something else...NOT CVD... Then again...these are the limitations of such studies... "The adjustment factors and the risk of bias among the studies are summarized in [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/table/pone-0055030-t002/'][B]Table 2[/B][/URL] and [B][URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030.s001']Table S1[/URL][/B], respectively. [B]Major confounding factors such as total energy intake were not stated in two studies. [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-GarciaPalmieri1'][23][/URL], [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-Massimino1'][32][/URL] Few inspected any updates of the carbohydrate intake over the follow-up period. [/B]Protein source was added to analysis in 3 studies. [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-Fung1'][7][/URL], [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-Lagiou1'][9][/URL], [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555979/#pone.0055030-Halton1'][30][/URL] The risk of bias among the researches involved in the meta-analysis was low." So we are free to interpret it in any way and wonder if it is really low carb... Frankly no one has any concrete data for long term effects of keto/low carb diet 5,10,15,20 years ...those who argue against it simply don't have the hard data at the moment because no researchers would be funded by pharma for such "dangerous" studies... [/QUOTE]
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