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Leptin resistance leads to type2 diabetes.

I'm now wondering if a thing called prediabetes if there is such a thing called preleptin deficiency?
Blood test targets is what is construed as leptin deficiency and what isn't.
Maybe they need looking at. Catch this problem earlier would prevent type2 diabetes in some.

I know research into meds for leptin defects currently but nothing yet.
They should try a child version of metformin maybe?
 
If I'd had metformin at 6yr old I may not have been so obese most of my life. That I'm sure of. Also I wouldnt have suffered infertility for 10yrs or needed to look at ivf, at all. Surely that would have saved the nhs thousands!
 
I was thin as a child. Thin as a teen. Thin as an adult - until I took seroxat I had no problem keeping the same weight, year in and year out.
 
serenity648 said:
I was thin as a child. Thin as a teen. Thin as an adult - until I took seroxat I had no problem keeping the same weight, year in and year out.
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My mum had a weight problem as a child but sisters didn't. They are saying leptin deficiency is hereditary like some other hereditary diabetes cases.
Is strange what is being discovered now.
Is Seroxat a steriod?
 
I was skinny as a rake my whole childhood. I have photos of me in my early teens and you can count my ribs.
I didn't really put on any weight till I left education and started an office job when I was about 21. Even then I put on weight slowly, a couple of pounds a year at first.

My mum used to feed me with Weetabix in the morning with a diet supplement (additional cereals) sprinkled on top followed by toast and marmalade every morning in a desperate effort to put weight on me :) I even took sugar in tea on those days!

Oh those days....
 
I didn't put excess weight on until I was somewhere over 35. Always slim and sporty. I went to weight watchers and lost 3 stone. Next weight increase was 10 years later and again back to weight watchers and 3 stone lost again. That lasted till my 60's but I wasn't obese, just borderline overweight/obese. Then diagnosis and 4 and a half stone lost on low carb. Maintained BMI of 21 since 2014.
 
I've never been skinny or anywhere close. At 13yr old I was size 22-24 and was depressed and eat out of boredom.
I have a photo of me being 7yr old and chubby.

My 10yr old is 5ft 5in and size adult uk8 shoe. He's classed as overweight on their projection sheet.

4yr old doesn't eat if he can help it. Milk and toast with occasional treat of a half bag of crisps and plain chocolate or a biscuit from his nana.
Oh he's overweight on their projection sheet.

Luckily the 10yr old is under Cambridge for rare genetic diseases for leptin deficiency bracket.
Now wondering if 4yr old has similiar too.

My mum has been overweight all her life, even on the now banned appetite suppresants of the early 80s from her gp.

Leptin is interlinked with insulin resistance.
I think this should be clarified more within the lepin resistance and deficiency bracket.
This article states can lead to type2 diabetes rather than is partnered with insulin resistance, which leads to type2 diabetes.

Now if leptin deficiency is normally picked up in infants. Could there be a version of it triggered in adulthood to cause type2.
E.g adult leptin deficiency leading to insulin resistance and type2 diabetes.

Maybe we've been looking in the wrong place for its cause??
Leptin malfunction maybe more the origin of type2 diabetes.

How many times have we seen posters having carb or protein cravings?
Leptin is the hunger hormone!!
 
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@serenity648 on the fatty liver threads it states some meds make fatty liver worse and some specialists monitor fatty liver, as course. Meds can interfer with other organs too.

Do you think you got fatty liver which lead to type2 then?
 
ickihun said:
My mum has taken antidepressants for decades and has a fatty liver but no diabetes.
I've read statins can cause type2 too.
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It may be that your mother hasnt got the diabetes gene. Seroxat definately raised my blood sugars by about 2 points or so when i took it after diagnosis. I had had a break of about 5 years. During which time, I stopped gaining weight again. I took it again for a year, my blood sugars went up, and i gained another stone.
 
serenity648 said:
It may be that your mother hasnt got the diabetes gene. Seroxat definately raised my blood sugars by about 2 points or so when i took it after diagnosis. I had had a break of about 5 years. During which time, I stopped gaining weight again. I took it again for a year, my blood sugars went up, and i gained another stone.
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Gosh. They are a godsend to people struggling to add weight then. Is there no alternative?
 
I think, for most people, the side effects are not an issue. Its just for some people, like me, the side effects, longterm, are worse than the illness. And they didnt ever work for me anyway, just made me feel sedated and numb emotionally. I have tried 6 different anitdepressants, and none have worked. Therapy, on the other hand, was brilliant.
 
It looks likely my son has the gene but his obesity isn't bad enough to construe injections. His gene is being investigated and we are hoping will help produce meds to combat even mild genetic congenical leptin deficiency obesity. He has slow sexual organ development which is associated with this gene fault.
I couldnt fertilize for over a decade without metformin.
I think metformin for children should be available to prevent type2 diabetes in children.
 
ickihun said:
I saw this and thought 'I wonder how many of us had obesity in childhood?'

http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=10886&Disease_Disease_Search_diseaseGroup=congenital-leptin-deficiency&Disease_Disease_Search_diseaseType=Pat&Disease(s)/group of diseases=Obesity-due-to-congenital-leptin-deficiency&title=Obesity-due-to-congenital-leptin-deficiency&search=Disease_Search_Simple
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@ickihun
I found this https://www.selfhacked.com/blog/the-root-causes-of-leptin-resistance-and-12-ways-to-reverse-it/ .. Its not exactly about leptin deficiency but insensitivity of insulin.

One thing I've been plagued with is, is poor sleep quality. My job has me spending way too much time in front of a computer, and getting "Blue light". I just recently put F.LUX on my computer https://justgetflux.com/ so it now has a pinkish hue to looking at the screen but my sleeping patterns have much improved. To cope with my T2DM I've exercised every afternoon / evening but I've found that after installing F.LUX I 've not needed to eat at the ultimate "Wrong" time of day (just before bedtime) and my sleep and health overall seems to be improving.. The above link to Selfhacked is IMO worth taking time to study..
 
Another interesting link

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099401/

Conclusion
The principal findings of the current study suggest that chronic sleep deprivation may predispose individuals to T2DM. Future, community-wide studies exploring the link between habitual sleep patterns, particularly poor sleep hygiene, and the cardiometabolic disorders, are needed using objective methods such as actigraphy and polysomnography to study sleep duration and sleep-related disorders.

Would thus be a fair assumption that if one changed one's habits and consistently got good sleep that one may improve one's health? I sense there is more to 8-9 hours of sleep than meets the eye!
 
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